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US 2010/0249226 A1Published application
Tumor selective and biodegradable cyclotriphosphazene-platinum(ii) conjugate anticancer agent, and preparation method thereof
AssigneeNanohybrid Co., Ltd.
InventorsYoun-Soo Sohn, Ji-Young Yu, Yong-Joo Jun
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Abstract
Disclosed are a novel cyclotriphosphazene-platinum(II) complex conjugate anticancer agent, showing high selectivity to tumor tissues due to the enhanced permeability and retention effect in tumor tissues and a preparation method thereof.
Claims17
A cyclotriphosphazene-platinum(II) complex conjugate represented by the following Chemical Formula 1:
- wherein n is 7, 12 or 16;
- m is 0, 1 or 2;
- x is 1, y and z are independently 0 or 1;
- R, R′ and R″ are independently selected from the group consisting of (CH3)2CH—, (CH3)2CHCH2—, (C2H5)(CH3)CH— and (C6H5)CH2—;
- and
- A and A′ represent two monodentate amine ligands which is identical to or different from each other, or A and A′ may be joined together to form a bidentate chelating diamine ligand.
3 more elements
Dependencies are inferred from the claim text.