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US 2010/0249221 A1Published application
In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
AssigneeBiovec, LLC
InventorsLakshman R. SEHGAL, Jonathan Wong
Life of this patent
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Abstract
A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
Claims22
1-30. (canceled)
A gutless adenovirus vector, comprising
- a polynucleotide encoding a therapeutic agent;
- a renal-specific regulatory element operably linked to said polynucleotide sequence;
- and
- a stuffer comprising the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15.
1 more element
A gutless adenovirus vector, comprising
- a polynucleotide encoding an indoleamine dioxygenase;
- a regulatory element operably linked to said polynucleotide sequence;
- and
- a stuffer comprising the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15.
1 more element
Dependencies are inferred from the claim text.