Method for the production of a cell and/or tissue and/or disease phase specific medicament
AssigneeSterna Biologicals GmbH & Co. KG
InventorsSerdar Sel, Harald Renz
Life of this patent
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Abstract
The invention relates to a method for the production of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell-type, tissue and/or stage specific proteins and nucleic acids are identified with regard to the modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and auto-immune diseases is provided.
Claims16
A method for producing a medicament for the treatment of chronic inflammations, characterized in that
- target cells are determined in which the expression of GATA-3 mRNA is higher than in healthy body cells,
- in vivo effective DNAzymes are developed, which bind to GATA-3 mRNA and functionally inactivate it,
- the in vivo effective DNAzymes are introduced into the target cells and
- medicaments containing the in vivo effective DNAzymes are formulated.
A method for producing a medicament for the treatment of chronic inflammations, characterized in that
- target cells are determined in which the expression of T-bet mRNA is higher than in healthy body cells,
- in vivo effective DNAzymes are developed, which bind to T-bet mRNA and functionally inactivate it,
- the in vivo effective DNAzymes are introduced into the target cells and
- medicaments containing the in vivo effective DNAzymes are formulated.
Dependencies are inferred from the claim text.