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US 2010/0249203 A1Published application
Compounds that inhibit trpv1 and uses thereof
AssigneeAbbott Laboratories
InventorsChih-hung Lee, Richard J. Perner, Brian S. Brown, John Darbyshire
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Abstract
Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Claims18
A compound of formula (I)
- or a pharmaceutically acceptable salt or prodrug thereof, wherein
- L is C1-C5 alkylene;
- R3 is C1-C5 alkyl;
- R7 is selected from the group consisting of hydrogen and halogen;
- and
- R9 is aryl;
- with the proviso that the following compounds are excluded:
- N-(4-chlorobenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(4-tert-butylbenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(3-fluoro-4-(trifluoromethyl)benzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(4-fluoro-3-(trifluoromethyl)benzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(3,4-dichlorobenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(2,4-dichlorobenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(4-ethylbenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(2-chlorobenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(4-fluorobenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-(2-fluorobenzyl)-N′-(1-methyl-1H-indazol-4-yl)urea,
- N-[1-(4-bromophenyl)ethyl-N′-(1-methyl-1H-indazol-4-yl)urea, and
- N-(1-methyl-1H-indazol-4-yl)-N′-{4-[(trifluoromethyl)thio]benzyl}urea.
16 more elements
Dependencies are inferred from the claim text.