Therapeutic use of n-(arylalkyl)-1h-pyrrolopyridine-2-carboxamide derivatives

A method for treating depression in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• n is equal to 0, 1, 2 or 3;
• the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group;
• X is chosen from a halogen atom and a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, —S(O)—C1-C6-alkyl, —S(O)2—C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5 or aryl group, the aryl being optionally substituted with one or more substituents chosen from a halogen and a C1-C6-alkyl, C3-C7cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, nitro or cyano group;
• Z1, Z2, Z3, Z4 and Z5 represent, independently of each other, a hydrogen or halogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, —S(O)—C1-C6-alkyl, —S(O)2—C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-C1-C6-alkylene or aryl group, the aryl and the aryl-C1-C6-alkylene being optionally substituted with one or more substituents chosen from a halogen and a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, nitro or cyano group;
• and wherein
• R1 and R2 represent, independently of each other, a hydrogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene or aryl group;
• or R1 and R2 together forming, with the nitrogen atom that bears them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine, homopiperazine group, this group being optionally substituted with a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene or aryl group;
• R3 and R4 represent, independently of each other, a hydrogen atom or a C1-C6-alkyl, aryl-C1-C6-alkylene or aryl group;
• R5 represents a C1-C6-alkyl or aryl group;
• and
• W represents a fused bicyclic group of formula:
• bonded to the nitrogen atom via positions 1, 2, 3 or 4;
• wherein
• A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N;
• the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, aryl, aryl-C1-C6-alkylene, oxo or thio group;
• and
• the nitrogen atom(s) of A being optionally substituted with R6 when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R7 in the other cases;
• wherein
• R6 represents a hydrogen atom or C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, aryl-C1-C6-alkylene or aryl group;
• R7 represents a hydrogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, aryl-C1-C6-alkylene, C1-C6-alkyl-C(O)—, C3-C7-cycloalkyl-C1-C3-alkylene-(CO)—, C1-C6-fluoroalkyl-C(O)—, C3-C7-cycloalkyl-C(O)—, aryl-C(O)—, aryl-C1-C6-alkylene-C(O)—, C1-C6-alkyl-S(O)2—, C1-C6-fluoroalkyl-S(O)2—, C3-C7-cycloalkyl-S(O)2—, C3-C7-cycloalkyl-C1-C3-alkylene-S(O)2—, aryl-S(O)2— or aryl-C1-C6-alkylene-S(O)2— or aryl group;
• the sulfur atom(s) of the heterocycle A possibly being in oxidized form;
• the nitrogen atom(s) of the heterocycle A possibly being in oxidized form;
• and
• the nitrogen atom in position 4, 5, 6 or 7 of the pyrrolopyridine may be in oxidized form.

A method for treating diabetes in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• n is equal to 0, 1, 2 or 3;
• the pyrrolopyridine nucleus is a pyrrolo[3,2-b]pyridine group, a pyrrolo[3,2-c]pyridine group, a pyrrolo[2,3-c]pyridine group or a pyrrolo[2,3-b]pyridine group;
• X is chosen from a halogen atom and a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, —S(O)—C1-C6-alkyl, —S(O)2—C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5 or aryl group, the aryl being optionally substituted with one or more substituents chosen from a halogen and a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, nitro or cyano group;
• Z1, Z2, Z3, Z4 and Z5 represent, independently of each other, a hydrogen or halogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, C1-C6-thioalkyl, —S(O)—C1-C6-alkyl, —S(O)2—C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-C1-C6-alkylene or aryl group, the aryl and the aryl-C1-C6-alkylene being optionally substituted with one or more substituents chosen from a halogen and a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxyl, C1-C6-fluoroalkoxyl, nitro or cyano group;
• and wherein
• R1 and R2 represent, independently of each other, a hydrogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene or aryl group;
• or R1 and R2 together forming, with the nitrogen atom that bears them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine, homopiperazine group, this group being optionally substituted with a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, aryl-C1-C6-alkylene or aryl group;
• R3 and R4 represent, independently of each other, a hydrogen atom or a C1-C6-alkyl, aryl-C1-C6-alkylene or aryl group;
• R5 represents a C1-C6-alkyl or aryl group;
• and
• W represents a fused bicyclic group of formula:
• bonded to the nitrogen atom via positions 1, 2, 3 or 4;
• wherein
• A represents a 5- to 7-membered heterocycle comprising from one to three heteroatoms chosen from O, S and N;
• the carbon atom(s) of A being optionally substituted with one or more groups chosen from a hydrogen atom and a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, aryl, aryl-C1-C6-alkylene, oxo or thio group;
• and
• the nitrogen atom(s) of A being optionally substituted with R6 when the nitrogen is adjacent to a carbon atom substituted with an oxo group, or with R7 in the other cases;
• wherein
• R6 represents a hydrogen atom or C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, aryl-C1-C6-alkylene or aryl group;
• R7 represents a hydrogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C3-alkylene, C1-C6-fluoroalkyl, aryl-C1-C6-alkylene, C1-C6-alkyl-C(O)—, C3-C7-cycloalkyl-C1-C3-alkylene-(CO)—, C1-C6-fluoroalkyl-C(O)—, C3-C7-cycloalkyl-C(O)—, aryl-C(O)—, aryl-C1-C6-alkylene-C(O)—, C1-C6-alkyl-S(O)2—, C1-C6-fluoroalkyl-S(O)2—, C3-C7-cycloalkyl-S(O)2—, C3-C7-cycloalkyl-C1-C3-alkylene-S(O)2—, aryl-S(O)2— or aryl-C1-C6-alkylene-S(O)2— or aryl group;
• the sulfur atom(s) of the heterocycle A possibly being in oxidized form;
• the nitrogen atom(s) of the heterocycle A possibly being in oxidized form;
• and
• the nitrogen atom in position 4, 5, 6 or 7 of the pyrrolopyridine may be in oxidized form.