Renin inhibitors

A compound of formula I, or a pharmaceutically acceptable salt thereof, having the formula (I)

• wherein
• R1 is selected from the group consisting of C1-6alkyl or C3-8cycloalkyl;
• R2 is an aryl ring, a 5 or 6-membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from N, O or S, or a fused 9 or 10-membered heteroaryl ring system containing 1, 2, 3 or 4 heteroatoms selected from N, O or S, wherein said aryl or heteroaryl ring is unsubstituted or mono-, di-, tri- or tetra-substituted with a group independently selected from
• 1) halogen,
• 2) O—C1-5alkylene-O—C1-5alkyl,
• 3) C1-5alkylene-O—C1-5alkyl,
• 4) C1-5alkylene-N(C1-5alkyl)-C(O)—C1-5alkyl,
• 5) C1-5alkylene-NH—C(O)—C1-5alkyl, and
• 6) oxo;
• R3 is an aryl ring, a 5 or 6-membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from N, O or S, a fused 9 or 10-membered heteroaryl ring system containing 1, 2, 3 or 4 heteroatoms selected from N, O or S, or C3-8 cycloalkyl, wherein said aryl ring, heteroaryl ring, or C3-8 cycloalkyl is unsubstituted or mono-, di-, tri- or tetra-substituted with a group independently selected from
• 1) halogen,
• 2) C1-5alkoxy,
• 3) CF3,
• 4) NH2,
• 5) O—(C1-5alkylene)-aryl,
• 6) C1-5 alkyl, and
• 7) oxo,
• R4 is selected from the group consisting of
• hydrogen,
• C1-5alkyl,
• C1-5alkylene-aryl,
• C1-5allylene-O—C1-5alkyl,
• C3-8cycloalkyl,
• C1-5alkyleneNHC(O)—C1-5alkyl,
• C(O)—O—C1-5alkyl, and
• C1-5alkylene-heteroaryl,
• wherein aryl is unsubstituted or mono- or di-substituted with halogen, alkyl is unsubstituted or mono- or di-substituted with OH, and heteroaryl is a 5 or 6 membered unsaturated ring containing 1, 2, 3 or 4 heteroatoms selected from the group consisting of N, O and S.