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US 2010/0249153 A1Published application
Substituted indolo-piperidine compounds
AssigneeArQule, Inc.
InventorsManish Tandon, Robert Nicewonger
Life of this patent
Estimating the term…
Abstract
The present invention relates to substituted indolo-piperidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-piperidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
Claims20
A compound having formula I:
- or a pharmaceutically acceptable salt or ester thereof, wherein:
- X is H or NHRx;
- X1 is N or CRx1;
- X2 is N or CRx2;
- R is H or unsubstituted or substituted C1-C6 alkyl;
- R1 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, C(O)Ra, C(O)ORa, C(O)NRaRb or -T-Q;
- R2 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, C(O)Ra, C(O)ORa, C(O)NRaRb, S(O)Ra, S(O)2Ra, S(O)2NRaRb or -T-Q;
- each R3 is independently halogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxy, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, C(O)Ra, C(O)ORa, C(O)NRaRb, NRaRb, NRaC(O)Rb, NRaC(O)ORb, NRaC(O)NRbRc, CN, NO2, ORa, SRa, S(O)Ra, S(O)2Ra, S(O)2NRaRb or -T-Q;
- m is 0, 1, 2, 3 or 4;
- Rx, Ra, Rb and Rc are each independently H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S or -T-Q;
- Rx1 and Rx2 are each independently H, halogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S or -T-Q;
- T is unsubstituted or substituted C1-C6 alkyl linker;
- and
- Q is unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S, C3-C10 unsubstituted or substituted carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered ring(s) and 1-4 heteroatoms selected from N, O and S.
11 more elements
Dependencies are inferred from the claim text.