New 4-substituted derivatives of pyrazolo[3,4-d pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof

A compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula:

• X represents CH or N;
• R represents H, alkylthio, alkylamino, cycloalkyl, cycloalkylthio, cycloalkylamino, alkyl, S(CH2)nOH, S(CH2)nNH2, NH(CH2)nOH, or NH(CH2)nNH2;
• R1 represents NH—R6 or N(R6)2;
• R6 represents an alkyl, cycloalkyl, 1-pyrrolidinyl, 4-morpholinyl, 1-hexahydroazepinyl or an aryl with the formula:
• in which X and Y are independently H or N;
• R6′, R7′, R8′, R9′, R10′ are independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl substituted groups, halo, haloalkyl, OCH3, NO2, CN, CONH2, CONH—C1-6 alkyl, CON(C1-6 alkyl)2, NH2, NH—C1-6 alkyl, N(C1-6 alkyl)2, NHC(O)alkyl, NHSO2—C1-6 alkyl, SO2NH2, SO2NHC1-6 alkyl, SO2N(C1-6 alkyl)2, OZ′ or SZ′ where Z′ is H, or alkyl, aryl or aralkyl substituted group, m is comprised between 0 and 4;
• R6 represents an aryl with the formula:
• in which V is N, S, or O;
• R11′, R12′, R13′, R14′, R15′ are independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl substituted groups, halo, haloalkyl, OCH3, NO2, CN, CONH2, CONH—C1-6 alkyl, CON(C1-6 alkyl)2, NH2, NH—C1-6 alkyl, N(C1-6 alkyl)2, NHC(O)alkyl, NHSO2—C1-6 alkyl, SO2NH2, SO2NHC1-6 alkyl, SO2N(C1-6 alkyl)2, OZ′ or SZ′ where Z′ is H, or alkyl, aryl or aralkyl substituted groups;
• m is comprised between 0 and 4;
• R2 represents H or an aryl with the formula:
• in which R16′, R17′, R18′, R19′, R20′ are independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl substituted groups, halo, haloalkyl, OCH3, NO2, CN, CONH2, CONH—C1-6 alkyl, CON(C1-6 alkyl)2, NH2, NH—C1-6 alkyl, N(C1-6 alkyl)2, NHC(O)alkyl, NHSO2—C1-6 alkyl, SO2NH2, SO2NHC1-6 alkyl, SO2N(C1-6 alkyl)2, OZ′ or SZ′ where Z′ is H, or alkyl, aryl or aralkyl substituted groups;
• m is comprised between 0 and 4;
• R4 represents
• wherein R21′, R22′, R23′, R24′, R25′ are independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl substituted groups, halo, haloalkyl, OCH3, NO2, CN, CONH2, CONH—C1-6 alkyl, CON(C1-6 alkyl)2, NH2, NH—C1-6 alkyl, N(C1-6 alkyl)2, NHC(O)alkyl, NHSO2—C1-6 alkyl, SO2NH2, SO2NHC1-6 alkyl, SO2N(C1-6 alkyl)2, OZ′ or SZ′ where Z′ is H, or alkyl, aryl or aralkyl substituted groups;
• and wherein R5 represents Cl, Br, OH, H, CH3.