Sulfonyl-substituted 6-membered ring derivative

A compound of a formula (I) or a pharmaceutically-acceptable salt thereof:

• wherein,
• Z is selected from a group consisting of the following formulae (II-1), (II-2) and (II-3):
• m and n each indicate 0, 1 or 2;
• Y represents CR3 or N, provided that when Y is N, then in (II-2) and (II-3), n is 0 or 2;
• R1 represents a C1-6 alkyl, a C3-8 cycloalkyl, an aryl or a heteroaryl, wherein the alkyl, the cycloalkyl, the aryl or the heteroaryl is unsubstituted or substituted with a substituent selected from a group consisting of a hydroxy, a cyano, a carboxyl, a sulfo, a halogen, a C1-6 alkyl, a halo-C1-6 alkyl, a C3-8 cycloalkyl, a C1-6 alkoxy, a halo-C1-6 alkoxy, an amino, a carbamoyl, a sulfanyl, a C1-6 alkylsulfinyl, an arylsulfinyl, a heteroarylsulfinyl, a C1-6 alkylsulfonyl, an arylsulfonyl, a heteroarylsulfonyl, a sulfamoyl, a C1-6 alkylsulfonylamino, an arylsulfonylamino, a heteroarylsulfonylamino, a C1-6 alkylcarbonyl, an arylcarbonyl, a heteroarylcarbonyl, a C1-6 alkoxycarbonyl, an aryloxycarbonyl, a heteroaryloxycarbonyl, a carbamoylamino, a C1-6 alkoxycarbonylamino, an aryloxycarbonylamino, a heteroaryloxycarbonylamino, a C1-6 alkylcarbonylamino, an arylcarbonylamino, a heteroarylcarbonylamino, an aryl, a heteroaryl, an aralkyl, a heteroaralkyl, an aralkyloxy and a heteroaralkyloxy, wherein the amino, carbamoyl, sulfanyl, sulfamoyl or carbamoylamino is unsubstituted or substituted with one or more C1-6 alkyl, aryl or heteroaryl;
• R2 represents a phenyl or a heteroaryl, wherein the phenyl or the heteroaryl is unsubstituted or substituted with a substituent selected from a group consisting of a hydroxy, a cyano, a carboxyl, a sulfo, a halogen, a C1-6 alkyl, a halo-C1-6 alkyl, a C3-8 cycloalkyl, a C1-6 alkoxy, a halo-C1-6 alkoxy, an amino, a carbamoyl, a sulfanyl, a C1-6 alkylsulfinyl, an arylsulfinyl, a heteroarylsulfinyl, a C1-6 alkylsulfonyl, an arylsulfonyl, a heteroarylsulfonyl, a sulfamoyl, a C1-6 alkylsulfonylamino, an arylsulfonylamino, a heteroarylsulfonylamino, a C1-6 alkylcarbonyl, an arylcarbonyl, a heteroarylcarbonyl, a C1-6 alkoxycarbonyl, an aryloxycarbonyl, a heteroaryloxycarbonyl, a carbamoylamino, a C1-6 alkoxycarbonylamino, an aryloxycarbonylamino, a heteroaryloxycarbonylamino, a C1-6 alkylcarbonylamino, an arylcarbonylamino, a heteroarylcarbonylamino, an aryl, a heteroaryl, an aralkyl, a heteroaralkyl, an aralkyloxy and a heteroaralkyloxy, wherein the amino, carbamoyl, sulfanyl, sulfamoyl or carbamoylamino is unsubstituted or substituted with one or more C1-6 alkyl, aryl or heteroaryl;
• R3 and R4 each independently represent a hydrogen atom, a C1-6 alkyl, a C3-8 cycloalkyl, an aralkyl, a heteroaralkyl, an aryl or a heteroaryl, wherein the alkyl, the cycloalkyl, the aralkyl, the heteroaralkyl, the aryl or the heteroaryl is unsubstituted or substituted with a substituent selected from a group consisting of a halogen, a C1-6 alkyl, a halo-C1-6 alkyl, a C1-6 alkoxy and a halo-C1-6 alkoxy;
• M1, M2, M3 and M4 each independently represent a hydrogen atom, or a C1-6 alkyl unsubstituted or substituted with a halogen;
• or M1, taken together with M2, M3 or M4, forms —CH2— or —CH2—CH2—, or M4, taken together with M2, forms —CH2— or —CH2—CH2—.

The compound or the pharmaceutically-acceptable salt thereof as claimed in claim 1, wherein the compound of formula (I) is selected from a group consisting of the following:

• (1R,3R)—N-(5-isopropoxypyridin-2-yl)-3-(phenylsulfonyl)cyclohexanecarboxamide,
• (1R,3R)—N-(5-isopropoxypyridin-2-yl)-3-(pyridin-2-ylsulfonyl)cyclohexanecarboxamide,
• (1R,3R)—N-(5-isopropoxypyridin-2-yl)-3-(pyrimidin-2-ylsulfonyl)cyclohexanecarboxamide,
• (1R,3R)—N-(5-isopropoxypyridin-2-yl)-3-(1,3-thiazol-2-ylsulfonyl)cyclohexanecarboxamide, and
• (1R,3R)—N-(3-isopropoxy-1H-pyrazol-5-yl)-3-(pyridin-2-ylsulfonyl)cyclohexanecarboxamide.