Method for inhibiting growth of cancer cells and cell telomere and diseases of cell proliferation by using heteroannelated anthraquinone derivative compounds

A compound of formula (III):

• wherein either one of R2 and R3 is one of:
• i) a first substituent being one of a hydryl group and a sulfuryl-group;
• and
• ii) a second substituent being one selected from a group consisting of a C1˜C8 alkyl group, a C1˜C8 alkoxyl group, a C3˜C8 nephthenic group, and a C3˜C8 cyclic alkoxyl group, a straight alkyl group with a branch substitutent, a nephthenic group with a branch substitutent by a straight C1˜C5 alkyl group and halogenated derivatives of the mentioned substituent groups.

A pharmaceutical composition, comprising:

• a therapeutically effective amount of a compound having a following formula (I):
• and at least one of an excipient and a carrier,
• wherein R1 is a substituent being one selected from a group consisting of:
• v) a first substituent being one selected from a group consisting of a hydryl group, an amino group, a nitro group, a hydroxyl group and a cyan group;
• vi) a second substituent being one selected from a group consisting of (CH2)nX, a straight (CH2)n alkyl group, a (CH2)n alkoxyl group, a branched (CH2)n alkyl group, a C3˜C12 nephthenic group, and a C3˜C12 cyclic alkoxyl group, wherein 1≦n≦12, and X is a halogen;
• vii) a third substituent being one selected from a group consisting of a straight C1˜C8 alkyl group with a double-bond, a C1˜C8 alkoxyl group with a double-bond, a branched C1˜C8 alkyl group with a double-bond and a C3˜C8 nephthenic group with a double-bond;
• and
• viii) a fourth substituent of a C5-C12 heterocyclic group.

A pharmaceutical composition, comprising:

• a therapeutically effective amount of a compound having a following formula (III):
• and at least one of an excipient and a carrier,
• wherein either one of R2 and R3 is one of:
• iii) a first substituent being one of a hydryl group and a sulfuryl-group;
• and
• iv) a second substituent being one selected from a group consisting of a C1˜C8 alkyl group, a C1˜C8 alkoxyl group, a C3˜C8 nephthenic group, and a C3˜C8 cyclic alkoxyl group, a straight alkyl group with a branch substituent, a nephthenic group with a branch substituent by a straight C1˜C5 alkyl group and halogenated derivatives of the mentioned substituent groups.