Back to results
US 2010/0249142 A1Published application
IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS
AssigneesUniversite de Montpellier I, American University of Beirut, Centre Regional De Lutte Contre Le Cancer De Montpellier CLRC
InventorsCarine Deleuze-Masquefa, Georges Moarbess, Pierre-Antoine Bonnet, Frédéric Pinguet, Ali Bazarbachi, Francoise Bressolle
Life of this patent
Estimating the term…
Abstract
Imidazo[1,2-a]quinoxaline compounds for the treatment of cancers as well as pharmaceutical compositions that include these compounds and their uses in therapy. The compound of general formula (I):
Claims22
Method of therapeutic treatment of cancer comprising administering an effective amount of a compound of formula (I):
- wherein
- R1, R2, R3 and R′ represent independently an atom of hydrogen, a halogen or a group chosen among the hydroxyl, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 thioalkyl, C1-C4 alkoxy, amino, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 acyl, C1-C4 aryl, C1-C4 aralkyl, optionally substituted by one or more substituents, and the cyano, nitroso, nitro, —CF3, —(CH2)nNR4R5, —(CH2)nCOR4, —(CH2)nCO—NR4R5, —(CH2)nSO2—NR4R5, —(CH2)nCO2R4, —NH—(CH2)nNR4R5 radicals,
- n ranging from 0 to 4,
- p ranging from 1 to 4,
- q ranging from 1 to 5,
- X representing (CH2)m, (CH2)mO(CH2)m′, (CH2)mNH(CH2)m′,
- m ranging from 0 to 4,
- m′ ranging from between 0 to 4,
- R4 and R5 represent independently an atom of hydrogen or group chosen among the linear or branched C1-C4 alkyl, linear or branched C1-C4 alkenyl, C3-C7 cycloalkyl radicals, and/or a physiologically acceptable salt thereof.
6 more elements
5-6. (canceled)
The compound of formula (V):
- wherein R1, R2, R3 and R′ represent independently an atom of hydrogen, a halogen or a group chosen among the hydroxyl, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 thioalkyl, C1-C4 alkoxy, amino, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 acyl, C1-C4 aryl, C1-C4 aralkyl, optionally substituted by one or more substituents, and the cyano, nitroso, nitro, —CF3, —(CH2)nNR4R5, —(CH2)nCOR4, —(CH2)nCO—NR4R5, —(CH2)nSO2—NR4R5, —(CH2)nCO2R4, —NH—(CH2)nNR4R5 radicals,
- n ranging from 0 to 4,
- p ranging from 1 to 4,
- q ranging from 1 to 5,
- X representing (CH2)m, (CH2)mO(CH2)m′, (CH2)mNH(CH2)m′,
- m ranging from 0 to 4,
- m′ from 0 to 4,
- R4 and R5 represent independently an atom of hydrogen or group chosen among the linear or branched C1-C4 alkyl, linear or branched C1-C4 alkenyl, C3-C7 cycloalkyl radicals, and/or a physiologically acceptable salt thereof.
5 more elements
The compound of formula (VI):
- wherein R1, R2, R3 and R′ represent independently an atom of hydrogen a halogen or a group chosen among the hydroxyl, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 thioalkyl, C1-C4 alkoxy, amino, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 acyl, C1-C4 aryl, C1-C4 aralkyl, optionally substituted by one or more substituents, and the cyano, nitroso, nitro, —CF3, —(CH2)nNR4R5, —(CH2)nCOR4, —(CH2)nCO—NR4R5, —(CH2)nSO2—NR4R5, —(CH2)nCO2R4, —NH—(CH2)nNR4R5 radicals,
- n ranging from 0 to 4,
- p ranging from 1 to 4,
- q ranging from 1 to 5,
- X representing (CH2)m, (CH2)mO(CH2)m′, (CH2)mNH(CH2)m′,
- m ranging from 0 to 4,
- m′ ranging from 0 to 4,
- R4 and R5 represent independently an atom of hydrogen or group chosen among the linear or branched C1-C4 alkyl, linear or branched C1-C4 alkenyl, C3-C7 cycloalkyl radicals, and/or a physiologically acceptable salt thereof.
5 more elements
The compound according to claim R of formula (VII):
- and/or a physiologically acceptable salt thereof.
The compound of formula (VIII):
- wherein R1, R2, R3 and R′ represent independently an atom of hydrogen, a halogen or a group chosen among the hydroxyl, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 thioalkyl, C1-C4 alkoxy, amino, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 acyl, C1-C4 aryl, C1-C1 aralkyl, optionally substituted by one or more substituents, and the cyano, nitroso, nitro. —CF3, —(CH2)nNR4R5, —(CH2)nCOR4, —(CH2)nCO—NR4R5, —(CH2)nSO2—NR4R5, —(CH2)nCO2R4, —NH—(CH2)nNR4R5 radicals,
- n ranging from 0 to 4,
- p ranging from 1 to 4,
- q ranging from 1 to 5,
- X representing (CH2)m, (CH2)mO(CH2)m′, (CH2)mNH(CH2)m′,
- m ranging from 0 to 4,
- m′ ranging from 0 to 4,
- R4 and R5 represent independently an atom of hydrogen or group chosen among the linear or branched C1-C4 alkyl, linear or branched C1-C4 alkenyl, C3-C7 cycloalkyl radicals, and/or a physiologically acceptable salt thereof.
5 more elements
23-25. (canceled)
Dependencies are inferred from the claim text.