Apoptosis promoters
AssigneeAbbott Laboraoties
InventorsMilan Bruncko, Hong Ding, Steven W. Elmore, Aaron R. Kunzer, Christopher L. Lynch, William J. McClellan, Cheol Min Park, Xiahong Song, Xilu Wang
Life of this patent
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Abstract
Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
Claims5
-11. (canceled)
A composition suitable for oral administration comprising an excipient and a compound having formula (II)
- or a therapeutically acceptable salt thereof,
- wherein
- X3 is Cl or F;
- X4 is azepan-1-yl, morpholin-1-yl, 1,4-oxazepan-4-yl, pyrrolidin-1-yl, N(CH3)2, N(CH3)(CH(CH3)2), 7-azabicyclo[2.2.1]heptan-1-yl or 2-oxa-5-azabicyclo[2.2.1]hept-5-yl, and R0 is
- wherein
- X5 is CH2, C(CH3)2 or CH2CH2;
- X6 and X7 are both hydrogen or are both methyl;
- and
- X8 is F, Cl, Br or I.
A composition suitable for oral administration comprising an excipient and N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazine-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide or a therapeutically acceptable salt thereof.
Dependencies are inferred from the claim text.