2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds

A compound of formula I,

• wherein
• A is C—R1b or N;
• R1a, R1b, R1c, R1d and R1e independently from each other are selected from the group consisting of:
• hydrogen;
• C1-7-alkyl;
• C2-7-alkenyl;
• C3-7-cycloalkyl-C1-7-alkyl;
• halogen;
• halogen-C1-7-alkyl;
• halogen-C1-7-alkoxy;
• halogen-C1-7-alkyl-sulfonyloxy;
• hydroxy;
• hydroxy-C1-7-alkyl;
• C1-7-alkoxy;
• C1-7-alkoxy-C1-7-alkoxy;
• hydroxy-C1-7-alkoxy;
• amino-C1-7-alkoxy;
• cyano;
• carboxyl;
• carboxyl-C1-7-alkyl;
• carboxyl-C1-7-alkoxy;
• C1-7-alkoxycarbonyl;
• C1-7-alkoxycarbonyl-C1-7-alkoxy;
• C1-7-alkoxycarbonylamino-C1-7-alkoxy;
• C1-7-alkylcarbonyloxy-C1-7-alkoxy;
• aminocarbonyl-C1-7-alkoxy;
• di-C1-7-alkylamino;
• di-C2-7-alkenylamino;
• C1-7-alkylsulfonyl-amino;
• carboxyl-C1-7-alkylaminocarbonyl;
• phenyl, said phenyl being substituted by a group selected from carboxyl, carboxyl-C1-7-alkyl, carboxyl-C1-7-alkoxy, C1-7-alkoxycarbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkoxycarbonyl-C1-7-alkoxy and aminocarbonyl, and, in addition, optionally substituted by one or two substituents selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy and halogen-C1-7-alkoxy;
• phenyloxy, wherein the phenyl ring is unsubstituted or substituted by one, two or three substituents selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy;
• carboxyl, carboxyl-C1-7-alkyl, carboxyl-C1-7-alkoxy, C1-7-alkoxycarbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkoxycarbonyl-C1-7-alkoxy and aminocarbonyl;
• heteroaryl selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl, said heteroaryl being unsubstituted or substituted by one, two or three substituents selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy, carboxyl, carboxyl-C1-7-alkyl, carboxyl-C1-7-alkoxy;
• C1-7-alkoxycarbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkoxycarbonyl-C1-7-alkoxy and aminocarbonyl;
• heteroaryloxy, wherein heteroaryl is selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl, and is unsubstituted or substituted by one, two or three substituents selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy;
• carboxyl, carboxyl-C1-7-alkyl, carboxyl-C1-7-alkoxy, C1-7-alkoxycarbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkoxycarbonyl-C1-7-alkoxy and aminocarbonyl;
• phenyl-C1-7-alkoxy, wherein the phenyl ring is unsubstituted or substituted by one, two or three substituents selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkyl, hydroxy, cyano, C1-7-alkylsulfonyl, C1-7-alkoxy, halogen-C1-7-alkoxy, carboxyl, carboxyl-C1-7-alkyl, carboxyl-C1-7-alkoxy, C1-7-alkoxy-carbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl and C1-7-alkoxycarbonyl-C1-7-alkoxy;
• and
• heterocyclyl or heterocyclylcarbonyl, wherein heterocyclyl is selected from the group consisting of pyrrolidine, piperidine and azepine and is substituted by carboxyl, carboxyl-C1-7-alkyl, carboxyl-C1-7-alkoxy, C1-7-alkoxycarbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl and C1-7-alkoxycarbonyl-C1-7-alkoxy;
• R2 is selected from the group consisting of C1-7-alkyl, C3-7-cycloalkyl-C1-7-alkyl, carboxyl-C1-7-alkyl, C1-7-alkoxycarbonyl-C1-7-alkyl, triazolyl-C1-7-alkyl and phenyl, said phenyl being unsubstituted or substituted by one, two or three halogen groups;
• R3 is hydrogen or C1-7-alkyl;
• or R2 and R3 together with the carbon atom they are attached to form a C3-C5-cycloalkyl ring;
• R4 is a heteroaryl ring selected from the group consisting of
• 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazinyl, 3,4-dihydro-2H-benzo[1,4]oxazinyl,
• 2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazinyl, 4-oxo-4H-quinolizinyl,
• 2-oxo-2,3-dihydro-1H-benzoimidazoyl, 2-oxo-2,3-dihydro-benzooxazolyl,
• benzo[1,3]dioxolyl, 2-oxo-1,2-dihydro-quinolinyl and
• 1,3-dimethyl-2,2-dioxo-2,3-dihydro-1H-22 6-benzo[1,2,5]thiadiazolyl,
• said heteroaryl ring being unsubstituted or substituted by one, two or three substituents selected from the group consisting of C1-7-alkyl, C2-7-alkenyl and halogen, or
• R4 is phenyl substituted by cyano and, in addition, optionally substituted by one or two substituents selected from the group consisting of halogen, halogen-C1-7-alkyl, C1-7-alkyl, C1-7-alkoxy and halogen-C1-7-alkoxy;
• and
• R5 is hydrogen or methyl;
• or a pharmaceutically acceptable salt thereof.