Compounds and methods for kinase modulation, and indications therefor

A compound having the structure of Formula IIIm:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R81 is selected from the group consisting of hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —OH, —NH2, —CN, —NO2, —C(O)OH, —S(O)2NH2, —C(O)NH2, —C(S)NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —OR68, —SR68, —NR69R68, —C(O)R68, —C(S)R68, —C(O)OR68, —C(O)NR69R68, —C(S)NR69R68, —S(O)2NR69R68, —NR69C(O)R68, —NR69C(S)R68, —NR69S(O)2R68, —NR69C(O)NH2, —NR69C(O)NR69R68, —NR69C(S)NH2, —NR69C(S)NR69R68, —NR69S(O)2NH2, —NR69S(O)2NR69R68, —S(O)R68, and —S(O)2R68;
• R83 is selected from the group consisting of hydrogen, fluoro and chloro;
• R112 is selected from the group consisting of optionally substituted C2-6 alkyl, optionally substituted aryl, optionally substituted heteroaryl, and —NR79R80;
• R68 is selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R68 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to N, S, O, S(O), S(O)2, C(O) or C(S) of —OR68, —SR68, —NR69R68, —C(O)R68, —C(S)R68, —C(O)OR68, —C(O)NR69R68, —C(S)NR69R68, —S(O)2NR69R68, —NR69C(O)R68, —NR69C(S)R68, —NR69S(O)2R68, —NR69C(O)NH2, —NR69C(O)NR69R68, —NR69C(S)NH2, —NR69C(S)NR69R68, —NR69S(O)2NH2, —NR69S(O)2NR69R68, —S(O)R68, or —S(O)2R68, optionally substituted lower alkynyl, provided, however, that when R68 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to N, S, O, S(O), S(O)2, C(O) or C(S) of —OR68, —SR68, —NR69R68, —C(O)R68, —C(S)R68, —C(O)OR68, —C(O)NR69R68, —C(S)NR69R68, —S(O)2NR69R68, —NR69C(O)R68, —NR69C(S)R68, —NR69S(O)2R68, —NR69C(O)NH2, —NR69C(O)NR69R68, —NR69C(S)NH2, —NR69C(S)NR69R68, —NR69S(O)2NH2, —NR69S(O)2NR69R68, —S(O)R68, or —S(O)2R68, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• R69 is selected from the group consisting of hydrogen and optionally substituted lower alkyl;
• and
• R79 and R80 are independently hydrogen or optionally substituted lower alkyl, or R79 and R80 combine with the nitrogen to which they are attached to form optionally substituted 5-7 membered heterocycloalkyl.

The compound of claim 5,

• wherein:
• lower alkyl as R68, R69, R79, R80, or R8, C2-6 alkyl as R112, lower alkenyl as R68 or R81, or lower alkynyl as R68 or R81 are optionally substituted with 1, 2, or 3 substituents selected from the group consisting of fluoro, —CN, —SR1a, —NR1aR1a, —C(O)R1a, —C(S)R1a, —C(O)OR1a, —C(O)NR1aR1a, —C(S)NR1aR1a, —S(O)2NR1aR1a, —NR1aC(O)R1a, —NR1aC(S)R1a, —NR1aS(O)2R1a, —S(O)R1a, —S(O)2R1a, cycloalkyl, heterocycloalkyl, aryl and heteroaryl;
• and
• cycloalkyl, heterocycloalkyl, aryl or heteroayl, as R68, R81, R112, or a substituent of lower alkyl, lower alkenyl or lower alkynyl are optionally substituted with 1, 2, or 3 substituents selected from the group consisting of halogen, —CN, —NR1aR1a, —SR1aR1a, —C(O)R1a, —C(S)R1a, —C(O)NR1aR1a, —C(S)NR1aR1a, —S(O)2NR1aR1a, —NR1aC(O)R1a, —NR1aC(S)R1a, —NR1aS(O)2R1a, —S(O)R1a, —S(O)2R1a, —R1b, and lower alkyl, wherein lower alkyl is optionally substituted with 1, 2 or 3 substituents selected from the group consisting of fluoro, —OH, —NH2, lower alkoxy, fluoro substituted lower alkoxy, lower alkylthio, fluoro substituted lower alkylthio, mono-alkylamino, di-alkylamino, and —Rib.