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US 2010/0249115 A1Published application
Substituted heterocyclic compounds
AssigneeArQule, Inc.
InventorsRobert Nicewonger, Audra Dalton, Chris Brassard, Mark A. Ashwell, Rocio Palma
Life of this patent
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Abstract
The present invention relates to substituted heterocyclic compounds and substituted tetrahydroisoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzodiazepine compounds and substituted tetrahydroisoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
Claims20
A compound of formula I:
- or a salt or ester thereof, wherein:
- one of Z1 and Z2 is CR3 the other is N;
- X2 and X4 are independently C(O) or CH2;
- X3 is CRaRb;
- Y is unsubstituted or substituted C1-C6 alkyl linker or a bond;
- m is 0, 1, 2, 3, 4;
- R1 is unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S, C(O)Rc or S(O)2Rc;
- R3 is H, halogen, unsubstituted or substituted C1-C8 alkyl, unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S;
- each R4 is independently hydroxyl, halogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxyl, amino, unsubstituted or substituted C1-C6 alkylamino, unsubstituted or substituted di-(C1-C6)alkylamino, unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S or any two adjacent R4's, together with the atoms to which they are attached, form a 5- to 7-member ring optionally comprising 1-4 optionally comprising 1-4 heteroatoms selected from N, O and S;
- Ra and Rb are independently H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S;
- and
- Rc is H, unsubstituted or substituted C1-C8 alkyl, unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S.
9 more elements
A compound of formula II:
- or a salt or ester thereof, wherein:
- one of Z1 and Z2 is CR3 the other is N;
- Z is —(CH2)n—, —CH2—O—(CH2)n— or a bond;
- m is 0, 1, 2, 3, 4;
- n is 1, 2, 3, 4, 5, 6;
- R3 is H, halogen, unsubstituted or substituted C1-C8 alkyl, unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S;
- each R4 is independently hydroxyl, halogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxyl, amino, unsubstituted or substituted C1-C6 alkylamino, unsubstituted or substituted di-(C1-C6)alkylamino, unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S or any two adjacent R4's, together with the atoms to which they are attached, form a 5- to 7-member ring optionally comprising 1-4 optionally comprising 1-4 heteroatoms selected from N, O and S;
- and
- R5 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C5-C10 aryl, unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising 1-4 heteroatoms selected from N, O and S.
6 more elements
Dependencies are inferred from the claim text.