Oxypiperidine derivatives and methods of use thereof

A compound having the structure:

• or a pharmaceutically acceptable salt, solvate, ester or prodrug thereof, wherein:
• Y is a bond, -alkylene-, —C(O)—, —OC(O)— or —NHC(O)—;
• R1 is aryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl or heteroaryl, wherein an aryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl or heteroaryl group can be optionally substituted with up to 3 substituents, which can be the same or different, and are selected from alkyl, —O-alkyl, halo, haloalkyl, —O-haloalkyl, —CN, —C(O)OR3, —N(R4)2, —C(O)N(R4)2, —C(O)R5, —NHC(O)R5, —NHS(O)2R3 or —S(O)2N(R4)2, and wherein R1 is cycloalkyl, the cycloalkyl group can be optionally fused to an aryl or heteroaryl ring;
• R2 is aryl, heterocycloalkyl, heterocycloalkenyl or heteroaryl, wherein an aryl, heterocycloalkyl, heterocycloalkenyl or heteroaryl group can be optionally substituted with up to 3 substituents, which can be the same or different, and are selected from alkyl, cycloalkyl, heterocycloalkyl, heteroaryl, —O-alkyl, —O-aryl, halo, haloalkyl, —O-haloalkyl, —CN, —OC(O)R5, —C(O)OR3, —N(R4)2, —C(O)N(R4)2, —C(O)R5, —NHC(O)R5, —NHS(O)2R3 or —S(O)2N(R4)2;
• each occurrence of R3 is independently H, alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl;
• each occurrence of R4 is independently H, alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl;
• each occurrence of R5 is independently H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, heteroaryl, —O-alkyl, —NH-alkyl, —O-aryl or —NH-aryl;
• p is an integer ranging from 0 to 2;
• q is an integer ranging from 0 to 2;
• r is an integer ranging from 0 to 2;
• and
• s is an integer ranging from 0 to 2.