Novel substituted tetrahydronaphthalenes, process for the preparation thereof and the use thereof as medicaments

A compound of formula I

• wherein:
• R1 and R2
• are each independently H, (C1-C8)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, (C3-C8)-alkenyl, (C3-C8)-alkynyl, CO(R9), (C(R10)(R11))q—R12, CO(C(R13)(R14))r—R15, CO—O(C1-C8)-alkyl, or CO(C(R13)(R14))r-N(R16)(R17);
• or
• R1 and R2 taken together with the nitrogen atom to which they are attached form a 4- to 10-membered mono-, bi- or spirocyclic ring which, apart from the nitrogen atom, may include from 0 to 3 additional heteroatoms selected from the group of oxygen, nitrogen and sulfur, where the heterocyclic ring system is optionally substituted by F, Cl, Br, CF3, CN, (C1-C8)-alkyl, (C3-C8)-cycloalkyl, O—(C1-C8)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, hydroxy-(C1-C6)-alkyl, oxo, CO(R18), CON(R19)(R20), hydroxyl, COO(R21), N(R22)CO(C1-C8)-alkyl, N(R23)(R24) or SO2(C1-C8)-alkyl;
• R10 and R11
• are each independently H, (C1-C8)-alkyl, hydroxy-(C1-C2)-alkyl, F, or OH;
• R9, R13, R14, R16, R17, R18, R19, R20, R21, R22, R23 and R24,
• are each independently H or (C1-C6)-alkyl;
• or
• R16 and R17, and R23 and R24
• each independently taken together with the nitrogen atom to which they are attached form a 5-6-membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatom from the group of NH, N—(C1-C6)-alkyl, oxygen and sulfur;
• q and r are each independently 0, 1, 2, 3, 4, 5, 6;
• R12 and R15
• are each independently H, OH, F, O—(C1-C6)-alkyl, S—(C1-C6)-alkyl, O-phenyl, CN, COO(R25), N(R26)CO(C1-C6)-alkyl, N(R27)(R28), CON(R29)(R30), SO2(C1-C6)-alkyl, or 3-12-membered mono-, bi- or spirocyclic ring which may contain one to four heteroatoms from the group of N, O and S, and the 3-12-membered ring is optionally substituted by F, Cl, Br, OH, CF3, NO2, CN, OCF3, oxo, O—(C1-C6)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, S—(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O—(C3-C8)-cycloalkyl, (C3-C8)-cycloalkenyl, O—(C3-C8)-cycloalkenyl, (C2-C6)-alkynyl, N(R31)(R32), COO(R33), SO2(C1-C6)-alkyl or COOH;
• R25, R26, R27, R28, R29, R30, R31, R32 and R33
• are each independently H or (C1-C8)-alkyl;
• or
• R27 and R28, R29 and R30, and R31 and R32
• each independently taken together with the nitrogen atom to which they are attached form a 5-6-membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatom from the group of NH, N—(C1-C6)-alkyl, oxygen and sulfur;
• L1 is C(R34)(R35), C(R36)(R37)C(R38)(R39), or (C3-C6)-cycloalkyl;
• optionally, R1 may be joined to one of the R34, R35, R36, R37, R38 or R39 radicals, so as to form a 5-6-membered ring;
• R34, R35, R36, R37, R38 and R39
• are each independently H or (C1-C8)-alkyl;
• R3, R4 and R5
• are each independently H, F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O—(C1-C6)-alkyl, S—(C1-C6)-alkyl, O—(C1-C4)-alkoxy-(C1-C4)-alkyl, (C1-C6)-alkyl, CON(R40)(R41) or CO(R42);
• R40, R41 and R42
• are each independently H or (C1-C8)-alkyl;
• or
• R40 and R41
• taken together with the nitrogen atom to which they are attached form a 5-6-membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatom from the group of NH, N—(C1-C6)-alkyl, oxygen and sulfur;
• X is O or C(R43)(R43′);
• R6, R6′, R7, R7′, R43 and R43′
• are each independently H, F, (C1-C8)-alkyl, OH, or O—(C1-C6)-alkyl;
• or
• R6 and R6′, or R43 and R43′ together are oxo;
• R8 is H or (C1-C8)-alkyl;
• L2 is a bond or C(R44)(R45);
• R44 and R45
• are each independently H or (C1-C8)-alkyl;
• A is a 5-6-membered aromatic ring which may include up to 2 heteroatoms selected from the group of nitrogen, oxygen and sulfur, and is optionally substituted by one or more of the substituents selected from H, F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O—(C1-C6)-alkyl, O—(C1-C4)-alkoxy-(C1-C4)-alkyl, (C1-C6)-alkyl, N(R54)(R55), SO2—CH3, CON(R56)(R57), N(R58)CO(R59), and CO(R60);
• provided that when L2 is a bond, then C(O)NR8 may be joined to an ortho substituent of A via a bridge containing one or two elements from the group of carbon and nitrogen, so as to form a 9- to 10-membered bicyclic ring overall;
• R54, R55, R56, R57, R58, R59, and R60
• are each independently H or (C1-C8)-alkyl;
• or
• R54 and R55, and R56 and R57
• each independently taken together with the nitrogen atom to which they are attached form a 5-6-membered ring which, apart from the nitrogen atom, may also include 0-1 further heteroatom from the group of NH, N—(C1-C6)-alkyl, oxygen and sulfur;
• L3 is a bond or a linker having from 1 to 4 members, where the members are selected from the group consisting of O, S, SO2, N(R61), CO, C(R62)(R63), C≡C, to give rise to a chemically viable radical, and the linker does not have any O—CO or COO groups;
• B is (C1-C6)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, hydroxy-(C1-C6)-alkyl, or a 3 to 10-membered mono-, bi- or spirocyclic nonaromatic ring which may include from 0 to 3 heteroatoms selected from the group of oxygen, nitrogen and sulfur, where the ring system is optionally substituted by one or more substituents selected from F, CF3, (C1-C6)-alkyl, O—(C1-C8)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, hydroxy-(C1-C4)-alkyl, oxo, CO(R64), and hydroxyl;
• and
• R61, R62, R63, and R64
• are each independently H or (C1-C8)-alkyl;
• provided that when X is C(R43)(R43′), then
• L3 is C(R62)(R63)O, and
• B is a 4- to 10-membered mono-, bi- or spirocyclic nonaromatic ring which includes from 1 to 3 heteroatoms selected from the group of oxygen, nitrogen and sulfur, where the ring system is optionally by one or more substituents selected from F, CF3, (C1-C6)-alkyl, O—(C1-C8)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, hydroxy-(C1-C4)-alkyl, oxo, CO(R64), and hydroxyl;
• or a physiologically compatible salt thereof.