Substituted Spiro-amide Compounds

A substituted spiro-amide compound corresponding to formula (I)

• wherein
• a represents 0 or 1;
• t represents 1, 2 or 3;
• b represents 0, 1 or 2;
• c, d, e and f each independently represent 0, 1 or 2;
• D represents one of the following groups D1 or D2
• q represents 0 or 1;
• s represents 0 or 1;
• r represents 1, 2 or 3;
• B represents C(═O), S(═O)2 or the group —C(═O)—N(R9), wherein the nitrogen atom thereof is bonded to R1;
• Q1 and Q2 each independently represent C, CH or N;
• R1 represents C1-6-alkyl, aryl, heteroaryl, —CH(aryl)2, C3-8-cycloalkyl or an aryl, heteroaryl or C3-8-cycloalkyl bonded via a C1-6-alkylene group, C2-6-alkenylene group or C2-6-alkynylene group, or an aryl or heteroaryl group bonded via a C3-6 cycloalkylene group;
• R2 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-6-alkylene group;
• R3 and R4 together with the group -Q1-Q2- joining them form a 4-, 5-, 6- or 7-membered which may be unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O—C1-6-alkyl, OH, OCF3, SH, SCF3, aryl and heteroaryl and/or optionally may be fused with at least one aryl or heteroaryl, wherein the ring may be saturated, unsaturated one or more times or aromatic, and may optionally contain one or more hetero atoms or hetero atom groups independently selected from the group consisting of N, NR50, O, S, S(═O) and S(═O)2;
• wherein
• R50 denotes H, C1-6-alkyl, —C(═O)—R51, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8- cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group, and
• R51 denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group;
• R5 represents 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of F, Cl, CF3, OCF3, OH, C1-6-alkyl and O—C1-6-alkyl, or two adjacent substituents R5 form a fused-on aryl, heteroaryl or C4-8-cycloalkyl ring;
• or two substituents R5 bonded to a carbon atom form a 3, 4 or 5 membered saturated carbocyclic ring, which may be unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, CF3 and C1-6-alkyl;
• R6 represents 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of F, Cl, Br, CF3, OCF3, OH, C1-6-alkyl, C3-8-cycloalkyl, O—C1-6-alkyl, NO2, NH2, N(H)(C1-6-alkyl) and N(C1-6-alkyl)2, or two adjacent substituents R6 form a fused-on aryl, heteroaryl or C4-8-cycloalkyl ring;
• R7 and R8 each independently represent 0, 1, 2, 3 or 4 substituents each independently selected from the group consisting of F, Cl, OH, ═O, C1-6-alkyl, O—C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl and a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-6-alkylene group, or two adjacent substituents R7 or R8 form a fused-on aryl or heteroaryl ring;
• R9 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group;
• X represents CR10aR10b, NR11 or O;
• Y represents CR12aR12b, NR13 or O;
• with the proviso that X does not denote NR11 if Y is NR13;
• and
• with the proviso that X and Y do not simultaneously denote O;
• wherein
• R10a, R10b, R12a and R12b each independently denote H, F, Cl, OH, C1-6-alkyl, O—C1-6-alkyl, C3-8-cycloalkyl, aryl or heteroaryl, or represent a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-6-alkylene group;
• or
• R10a and R10b together can represent ═O;
• or
• R12a and R12b together can represent ═O;
• R11 and R13 each independently represent H, C1-6-alkyl, C3-8-cycloalkyl, aryl or heteroaryl, or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-6-alkylene group;
• Z represents CR14aR14b;
• NR15 or O;
• R14a represents H, NR16R17, C1-6-alkylene-NR16R17, O—C1-6-alkylene-NR16R17, C(═O)—NR16R17, C(═O)—C1-6-alkylene-NR16R17, OR18, C1-6-alkylene-OR18, C1-6-alkylene-O—C1-6-alkylene-OR18, C1-6-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl, or denotes a C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl group bonded via a C1-6-alkylene group,
• R14b represents H, NR16R17, C1-6-alkylene-NR16R17, O—C1-6-alkylene-NR16R17, C(═O)—NR16R17, C(═O)-C1-6-alkylene-NR16R17, OR18, C1-6-alkylene-OR18, C1-6-alkylene-O—C1-6-alkylene-OR18, C1-6-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl, or denotes a C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl group bonded via a C1-6-alkylene group,
• R15 represents H, —C(═O)—R19, —S(═O)2—R19, —C(═O)-N(R20)—R19, CHR25R26, C1-10-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl or denotes a CHR25R26, C3-8-cycloalkyl, heterocyclyl, aryl or heteroaryl group bonded via a C1-6-alkylene group;
• R16 and R17 each independently represent H, C1-6-alkyl or C3-8-cycloalkyl, or
• R16 and R17 together with the nitrogen atom to which they are bound form a 4-, 5-, 6- or 7-membered heterocyclic ring, which may be unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O—C1-6-alkyl, OH, OCF3, SH, SCF3, NRARB, aryl and heteroaryl and/or optionally may be fused with at least one aryl or heteroaryl ring, wherein the heterocyclic ring may be saturated or unsaturated one or more times, and may optionally contain one or more hetero atoms or hetero atom groups independently selected from the group consisting of N, NR50a, O, S, S(═O) and S(═O)2;
• wherein
• R50a denotes H, C1-6-alkyl, —C(═O)—R51a, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group, and
• R51a denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group;
• R18 represents H, C1-6-alkyl, C3-8-cycloalkyl, heterocyclyl, aryl, heteroaryl or C2-6-alkylene-NR16R17 or denotes a heterocyclyl, C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-6-alkylene group;
• R19 represents C1-6-alkyl, aryl, heteroaryl, —CH(aryl)2, C3-8-cycloalkyl, heterocyclyl or an aryl, heteroaryl, C3-8-cycloalkyl or heterocyclyl group bonded via a C1-6-alkylene group, C2-6-alkenylene group or C2-6-alkynylene group;
• R20 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group;
• or
• if X represents O and f represents 0, then Z may denote —(C(R21)—C(R22))—, wherein R21 and R22 together with the carbon atoms joining them form a fused-on aryl or heteroaryl ring;
• or
• if X represents O and f represents 0, then Z may denote ═(N(CR23))—, wherein the N atom is bonded to the O atom via a single bond, and R23 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl or heteroaryl or denotes a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-6-alkylene group;
• R25 and R26 each independently represent H, C3-8-cycloalkyl, aryl or heteroaryl, or
• R25 and R26 together with the CH grouping joining them form a 4-, 5-, 6- or 7-membered ring, which may be unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O—C1-6-alkyl, OH, OCF3, SH, SCF3, NRARB, aryl and heteroaryl, wherein the ring may be saturated or unsaturated one or more times, but is not aromatic, and optionally may contain one or more hetero atoms or hetero atom groups independently selected from the group consisting of N, NR50b, O, S, S(═O) and S(═O)2;
• wherein
• R50b denotes H, C1-6-alkyl, —C(═O)—R51b, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8- cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group, and
• R51b denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group;
• RA and RB each independently represent H, C1-6-alkyl or C3-8-cycloalkyl, or
• RA and RB together with the nitrogen atom to which they are bound form a 4-, 5-, 6- or 7-membered heterocyclic ring, which may be unsubstituted or substituted on one or more of its carbon ring members by one or more substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O—C1-6-alkyl, OH, OCF3, SH, SCF3, aryl and heteroaryl, wherein the heterocyclic ring may be saturated or unsaturated one or more times, but is not aromatic, and optionally may contain one or more hetero atoms or hetero atom groups independently selected from the group consisting of N, NRC, O, S, S(═O) and S(═O)2;
• wherein
• RC denotes H, C1-6-alkyl, —C(═O)—RD, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group, and
• RD denotes C1-6-alkyl, C3-8-cycloalkyl, aryl, heteroaryl or a C3-8-cycloalkyl, aryl or heteroaryl group bonded via a C1-3-alkylene group;
• wherein the aforementioned C1-4-alkyl, C1-6-alkyl, C1-10-alkyl, C1-3-alkylene, C1-6-alkylene, C2-6-alkylene, C2-6-alkenylene, C2-6-alkynylene, C3-8-cycloalkyl, C4-8-cycloalkyl, heterocyclyl, aryl and heteroaryl groups may each be unsubstituted or substituted one or more times by identical or different substituents, and the abovementioned C1-6-alkyl, C1-10-alkyl, C1-3-alkylene, C1-6-alkylene, C2-6-alkylene, C2-6-alkenylene and C2-6-alkynylene groups may each be branched or unbranched;
• or a physiologically acceptable salt thereof.