Compounds for the Treatment of Hepatitis C

A compound of formula I

• R1 is R5R6N;
• alkoxy;
• (alkoxycarbonylamino)alkoxy;
• (alkylphenyl)alkoxy;
• (carboxy)alkenyl;
• (alkoxycarbonyl)alkenyl;
• (benzyloxycarbonyl)alkenyl;
• ((N-dimethylbenzyl)aminocarbonyl)alkenyl;
• or phenyl where said phenyl is substituted with 1-2 substituents selected from the group consisting of halo, cyano, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (carboxy)alkyl, alkoxy, hydroxyalkyloxy, alkoxyalkyloxy, benzyloxy, tetrahydropyranyloxy, carboxy, alkoxycarbonyl, alkylsulfonyl, (carboxy)alkenyl, (alkoxycarbonyl)alkenyl, alkylcarboxamido, alkoxycarboxamido, alkylsulfamido, (alkylsulfamido)alkyl, Ar5, SO2NR15R16, and CONR7R8;
• and where said phenyl is also substituted with 0-2 substituents selected from the group consisting of halo;
• nitro;
• alkyl;
• cycloalkyl;
• haloalkyl;
• aminoalkyl;
• hydroxyalkyl;
• alkoxyalkyl;
• hydroxy;
• alkoxy;
• OR17;
• cycloalkoxy;
• amino;
• alkylamino;
• dialkylamino;
• alkylcarboxamido;
• alkoxycarboxamido;
• alkoxyalkylcarboxamido;
• furanyl, thienyl, or pyrazolyl substituted with 0-2 alkyl substituents;
• pyridinyl substituted with 0-2 halo, cyano, alkyl, hydroxy, alkoxy, amino, or alkylaminocarbonyl substituents;
• pyrimidinyl;
• pyrimidinedionyl;
• aminopyrimidinyl;
• indolyl;
• isoquinolinyl;
• and phenyl substituted with 0-2 substituents selected from the group consisting of halo, alkyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, hydroxy, alkoxy, amino, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylcarboxamido, carboxyalkenyl, and phenyl;
• R2 is hydrogen, halo, nitro, amino, phenyl, or R5R6N;
• R3 is cyano, alkoxycarbonyl, (cycloalkyl)oxycarbonyl, (alkylsulfonyl)aminocarbonyl, CONR11R12, (R11)(R12)NCONH, triazolyl, thiazolyl, or tetrazolyl;
• R4 is phenyl substituted with 0-2 halo substituents;
• R5 is hydrogen, alkyl, or alkylsulfonyl;
• R6 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or alkylsulfonyl;
• R7 is hydrogen, alkyl, alkenyl, alkynyl, cyanoalkyl, haloalkyl, hydroxyalkyl, dihydroxyalkyl, alkoxyalkyl, oxoalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, (cycloalkyl)alkyl, cycloalkyl, (alkyl)cycloalkyl, (hydroxyalkyl)cycloalkyl, (tetrahydrofuranyl)alkyl, (tetrahydropyranyl)alkyl, (carboxy)alkyl, (alkoxycarbonyl)alkyl, (alkenyloxycarbonyl)alkyl, (alkoxycarbonyl)hydroxyalkyl, (CONR13R14)alkyl, (CONR13R14)(hydroxyalkyl)alkyl, (CONR13R14)cylcoalkyl, (alkylcarbonyl)aminoalkyl, (phenyl)alkyl, (pyridinyl)alkyl, alkylsulfonyl, phenylsulfonyl, Ar2, Ar3,
• R8 is hydrogen, alkyl, hydroxyalkyl, or alkoxyalkyl;
• or R7R8N taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, dihydroindolyl, or isoindolinyl, and is substituted with 0-2 substituents selected from alkyl, hydroxyalkyl, alkoxyalkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, dialkylcarboxamido, alkylcarbonylamino, alkoxycarbonylamino, pyridinyl, and phenyl where said phenyl is substituted with 0-2 halo or alkyl substituents;
• or where R7R8N taken together is
• (quinuclidinyl)amino, (quinuclidinyl)(alkyl)amino, (methylpyrrolidinyl)(alkyl)amino, ((imidazolyl)alkyl)(hydroxyalkyl)amino, (alkylthiazolyl)amino, ((carboxamido)cyclopentanyl)amino, ((halophenyl)cyclopentanyl)amino, 3H-spiro(isobenzofuranyl)piperidinyl, (hydroxyindanyl)amino, or
• R9 is hydrogen, alkyl, hydroxyalkyl, or alkoxyalkyl;
• R10 is hydrogen, alkyl, hydroxyalkyl, or alkoxyalkyl;
• or R9 and R10 taken together is ethylene, propylene, butylene, pentylene, or hexylene;
• R11 is hydrogen, alkyl, or cycloalkyl;
• R12 is hydrogen, alkyl, or cycloalkyl;
• or R11 and R12 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl;
• R13 is hydrogen, alkyl, cyanoalkyl, haloalkyl, alkenyl, alkynyl, or thiazolyl;
• R14 is hydrogen or alkyl;
• R15 is hydrogen, alkyl, hydroxyalkyl, cycloalkyl, or benzyl;
• R16 is hydrogen or alkyl;
• or R15 and R16 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl;
• R17 is haloalkyl, cyanoalkyl, (cycloalkyl)alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, (R18)alkyl, (Ar4)alkyl, alkynyl, or aminocycloalkyl;
• R18 is CONH2, H2NCONH, dibenzylamino, phthalimido, amino, alkylamino, dialkylamino, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl where azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl is substituted with 0-3 alkyl or alkoxycarbonyl substituents;
• R19 is cyano, hydroxyalkyl, morpholinylalkyl, carboxy, alkoxycarbonyl, cycloalkylsulfoxamido, ((alkyl)pyrazolyl)amino, ((alkyl)isoxazolyl)amino, (thiadiazolyl)amino, (triazinyl)amino, or alkynylaminocarbonyl;
• R20 is hydrogen, halo, alkyl, or alkoxy;
• R21 is hydrogen, halo, alkyl, or alkoxy;
• Ar1 is phenyl, naphthalenyl, pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, oxadiathiazolyl, triazolyl, tetrazolyl, pyrazinyl, pyrimidinyl, or benzothiazolyl, and is substituted with 0-2 substituents selected from halo, alkyl, cycloalkyl, haloalkyl, alkoxyalkyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, aminocarbonyl, pyridinyl, phenyl, halophenyl, alkylphenyl, and alkoxyphenyl;
• Ar2 is phenyl, biphenyl, or pyridinyl and is substituted with 0-2 substituents selected from halo, alkyl, cyano, hydroxy, alkoxy, and carboxy;
• Ar3 is pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, oxathiadiazolyl, pyrimidinyl, or pyrizinyl and is substituted witlh 0-2 substituents selected from hydroxy, alkyl, hydroxyalkyl, and CONR13R14;
• Ar4 is furanyl, thienyl, pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridinyl, indolyl, or phenyl and is substituted with 0-2 substituents selected from halo, alkyl, haloalkyl, hydroxyl, and alkoxy;
• and
• Ar5 is pyrrozolyl, imidazolyl, or oxadiazolyl and is substituted with 0-2 substituents selected from alkyl, carboxy, alkoxycarbonyl, benzyl, and phenyl;
• or a pharmaceutically acceptable salt thereof.