Substituted pyrimidines as adenosine receptor antagonists

A compound of formula (I)

• or a pharmaceutically acceptable salt, ester, solvate or stereoisomer thereof, wherein:
• R1 is a heterocycle optionally substituted by one or more members selected from the group of lower alkyl, lower alkoxy, halogen and cyano;
• R2 is phenyl or pyridyl, wherein the phenyl or pyridyl ring is substituted by 1 to 4 R4 groups;
• or
• R2 is isoquinoline, dihydroisoquinoline or tetrahydroisoquinoline ring, wherein the isoquinoline, dihydroisoquinoline or tetrahydroisoquinoline ring is optionally substituted by R5;
• R3 is H, R7, COR7, CONR7R8, or COOR7;
• R4 is at each occurrence selected from the group of halogen, —(X)m—(O), —(Y)p—R5, or —(X)m—(O)n—(Y)p—NR5R6;
• each of R5 and R6 is independently hydrogen, lower alkyl, lower C2-6 alkoxy, lower C2-6 alkoxyalkyl, lower C2-6 hydroxyalkyl, cyano, C(O)—C1-C6alkyl or C(O)O—C1-C6alkyl;
• or
• R5 and R6 together with the nitrogen to which they are attached form a heterocyclic ring optionally substituted by one or more members selected from the group of halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkoxyalkyl, lower hydroxyalkyl, cyano, and —C(O)—C1-C6alkyl;
• R7 is lower alkyl optionally substituted by one or more members selected from the group of lower alkyl, lower alkoxy, hydroxyl, halogen, amino, alkylamino and dialkylamino;
• R8 is selected from the group of lower alkyl, lower alkoxy, alkoxyalkyl, —C(O)—C1-C6alkyl or lower alkenyl, wherein the lower alkyl, lower alkoxy, alkoxyalkyl, —C(O)—C1-C6alkyl, and lower alkenyl groups are optionally substituted by one or more lower alkyl, halogen, lower alkoxy, hydroxyl, or cyano;
• or
• R7 and R8 together with the nitrogen to which they are attached form a heterocyclic ring optionally substituted by one or more members selected from the group of halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkoxyalkyl, lower hydroxyalkyl and cyano;
• each of X and Y is independently lower alkyl, cycloalkyl or saturated heterocyclyl;
• m is at each occurrence 0 or 1;
• n is at each occurrence 0 or 1;
• and
• p is at each occurrence 0 or 1.