Modulators of hypoxia inducible factor-1 and related uses

A compound of formula I:

• or a pharmaceutically acceptable salt or prodrug thereof, wherein:
• R is a nitrogen-containing C2-6 heterocyclyl group joined to the (CH2)n linkage by means of its nitrogen atom and optionally substituted with a C1-5 alkyl, C1-5 hydroxyalkyl, C1-5 halogenoalkyl or C1-5 acyl group, a phenyl group or a C1-5 alkyl group further substituted with a phenyl group,
• R is a group R′R″N— with R′ and R″ independently equal to H, C1-5 alkyl or methylenecyclopropyl, and
• n is an integer in the range 2 to 5,
• with the proviso that, when R represents an unsubstituted piperidino group or a dimethylamino group, then n does not equal 2.