Compositions and methods for treatment of renal disease
OwnerAjay Guptainventor
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Abstract
The invention relates to methods, compositions, and kits for the treatment of proteinuria and/or hypertension (e.g., proteinuria and/or hypertension arising from primary renal disease (e.g., focal segmental glomerulosclerosis, glomerular disease) or secondary to other conditions (e.g., diabetes, diabetic nephropathy, liver disease). Specifically, the invention relates to methods involving combination therapy wherein an indoline (e.g., indapamide) is administered in combination with an anti-aldosterone agent (e.g., spironolactone and/or epleronone).
Claims22
A composition comprising an indoline and an anti-aldosterone agent.
A method for treating or preventing a condition selected from the group consisting of proteinuria, albuminuria, sodium retention, hypokalemia, hyperkalemia, hyperuricemia, dyslipidemia, and hyperglycemia in a subject comprising:
- a) providing a subject suffering from or at risk for a condition selected from the group consisting of proteinuria, albuminuria, sodium retention, hypokalemia, hyperkalemia, hyperuricemia, dyslipidemia, and hyperglycemia;
- b) providing a combination therapy comprising an indoline and an anti-aldosterone agent;
- and
- c) measuring a benefit related to a condition selected from the group consisting of proteinuria, albuminuria, sodium retention, hypokalemia, hyperkalemia, hyperuricemia, dyslipidemia, and hyperglycemia.
A method of treating a subject with a disease selected from the group consisting of impaired insulin signaling, diabetes mellitus, type I diabetes, type II diabetes, gestational diabetes, metabolic syndrome, metabolic syndrome X, syndrome X, insulin resistance syndrome, Reaven's syndrome, CHAOS, malnutrition-related diabetes mellitus, diabetic nephropathy, nephropathy, glomerular disease, liver disease, renal disease, membranous glomerulonephritis, severe cardiac failure, nephrotic syndrome, systemic lupus erythematosus, Goodpasture's syndrome, IgA nephropathy, Alport syndrome, acute post-streptococcal glomerulonephritis (PSGN), bacterial endocarditis, HIV-induced nephropathy, glomerulosclerosis, focal segmental glomerulosclerosis (FSGS), membranous nephropathy (membranous glomerulopathy), obesity, minimal change disease (MCD), heart failure, hypertension, liver failure, acute renal failure, chronic kidney disease, congestive heart failure, proteinuric kidney disease, diabetic nephropathy, glomerulonephritis, amyloidosis, and drug-induced renal disease comprising administering a composition comprising an indoline and an anti-aldosterone agent.
A method of promoting a state in a subject, said state selected from the group consisting of homeostasis of serum potassium level, homeostasis of serum uric acid level, normal cardiac ventricular rhythm, and normal QT interval comprising administering a composition comprising an indoline and an anti-aldosterone agent.
Dependencies are inferred from the claim text.