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US 2010/0249076 A1Published application
Prodrugs of 9-aminomethyl tetracycline compounds
AssigneeParatek Pharmaceuticals, Inc.
InventorsVictor Amoo, Haregewein Assefa, Beena Bhatia, Joel Berniac, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Oak K. Kim, Rachid Mechiche, Kwasi Ohemeng, Jingwen Pan
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Abstract
The invention pertains to prodrugs of 9-aminomethyl substituted tetracycline compounds, methods of using the compounds, and pharmaceutical compositions containing them.
Claims20
A compound of the formula (I):
- wherein
- E is oxygen, nitrogen, or a covalent bond;
- G is alkyl;
- heterocyclicalkyl;
- aryl;
- alkylcarbonyloxyalkyl;
- arylcarbonyloxyalkyl;
- alkyloxycarbonyloxyalkyl;
- arylalkylcarbonyloxyalkyl;
- alkyloxyalkylcarbonyloxyalkyl;
- alkoxyalkoxycarbonyloxyalkyl, and pharmaceutically acceptable salts thereof.
8 more elements
A compound of the formula (II):
- wherein
- Q′ is a prodrug moiety and pharmaceutically acceptable salts thereof.
A compound selected from the group consisting of:
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.