Benzyl-cycloalkyl sphingosine 1-phosphate receptor modulators

A compound of the formula:

• wherein R4 is C, CH, or N;
• R5, R6 and R7 are independently is CH, CH2, O, S, N, or NRa;
• X is hydroxyl, carboxylic acid, methylene carboxylic acid, alpha-substituted carboxylic acid, phosphate, phosphonate, or alpha-substituted phosphonate;
• R1 is hydrogen, halo, tri-fluoromethyl, (C1-C10) alkyl, halo(C1-C10) alkyl, hydroxy-(C1-C10) alkyl, (C1-C10) alkoxy(C1-C10) alkyl, or cyano(C1-C10) alkyl;
• and
• R2 is hydrogen, halo, (C1-C20)alkyl, (C1-C20)alkoxy;
• (C2-C26) alkoxyalkyl;
• (C2-C20)alkenyl, (C2-C20)alkynyl, (C3-C12)cycloalkyl, (C1-C20)alkyl-(C3-C12)cycloalkyl, (C6-C10)aryl, (C1-C20)alkyl(C6-C10)aryl, (C6-C10)aryl(C1-C20)alkyl, and aryl substituted arylalkyl;
• wherein one or more of the carbon atoms in the R2 groups can be independently replaced with non-peroxide oxygen, sulfur or NRa;
• the alkenyl, alkynyl, cycloalkyl, aryl, heterocyclic, or heteroaryl groups of R1, R2, or X are optionally substituted with 1, 2, 3, or 4 groups where the substituent groups are independently hydroxy, halo, cyano, (C1-C10)alkyl, (C1-C10)alkoxy, C6-aryl, (C7-C24)arylalkyl, oxo (═O), or imino (═NRa);
• Ra is hydrogen, or (C1-C10)alkyl;
• and n is 0, 1, 2, 3, or 4;
• indicates one or more optional double bonds, and the alkyl groups of Ra are optionally substituted with 1, or 2 hydroxy groups;
• or a pharmaceutically acceptable salt or ester thereof.