Methods of modulating inflammatory cell recruitment and gene expression using haloaryl substituted aminopurines

A method for inhibiting inflammatory cell recruitment or inhibiting inflammatory gene expression, comprising administering to a patient in need thereof an effective amount of a compound having the formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is substituted or unsubstituted C1-6alkyl, substituted or unsubstituted aryl, substituted or unsubstituted C3-10cycloalkyl, substituted or unsubstituted C3-10heterocycle or substituted or unsubstituted C3-10heteroaryl;
• R2 is H, substituted or unsubstituted C1-6alkyl, substituted or unsubstituted aryl, substituted or unsubstituted C3-10cycloalkyl, substituted or unsubstituted C3-10heterocycle or substituted or unsubstituted C3-10heteroaryl;
• and
• R3 is aryl substituted with one or more halogens or C3-10heteroaryl substituted with one or more halogens, wherein the aryl or C3-10heteroaryl group is optionally further substituted with one or more C1-6alkyl, hydroxyl, hydroxyalkyl, alkoxy, alkoxyalkyl, amino, alkylamino, carboxy, aminocarbonyl, cyano, acylamino, alkanesulfonylamino, tetrazolyl, triazolyl or imidazolyl groups.