Methods and compositions for treating diseases and conditions involving higher molecular weight hyaluronan
AssigneeThe University of Chicago
InventorsPatrick A. Singleton, Joe G.N. Garcia
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Abstract
The present invention concerns methods and compositions involving hyaluronan that has been substantially purified to enrich for hyaluronan with a molecular weight above 500 kilodaltons. This hyaluronan can be used for diseases and conditions characterized or caused by increased vascular permeability or angiogenesis. The higher molecular weight hyaluronan restores vascular integrity and inhibits angiogenesis in embodiments of the invention.
Claims24
A method for regulating vascular permeability in a subject having symptoms of or diagnosed with a disease or condition involving increased vascular permeability comprising administering to the subject an effective amount of a composition comprising substantially purified hyaluronan, wherein the hyaluronan is at least about 95% pure hyaluronan with a molecular weight greater than about 500 kilodaltons.
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A method for regulating vascular permeability in a subject having a disease or condition involving increased vascular permeability comprising administering to the subject an effective amount of a composition comprising purified hyaluronan, wherein more than 95% of the hyaluronan in the composition has a molecular weight of at least about 500 kilodaltons.
A method for treating a lung disease or condition involving endothelial cells in the lungs comprising administering to a patient in need of such treatment an effective amount of a composition comprising purified hyaluronan, wherein the hyaluronan has a molecular weight above about 500 kilodaltons.
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Dependencies are inferred from the claim text.