Oligosaccharides, preparation method and use thereof, and pharmaceutical compositions containing same
AssigneeAventis Pharma S.A.
InventorsChristian VISKOV, Pierre MOURIER
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Abstract
The invention relates to oligosaccharides, the preparation method and use thereof, and pharmaceutical compositions containing same. More specifically, the invention relates to oligosaccharides which can be used for the treatment of cancer and, in particular, to prevent and inhibit the formation of metastases. The inventive oligosaccharides can be used, for example, during early breast, lung, prostate, colon or pancreatic cancer. The oligosaccharides can be administered subcutaneously, orally or intravenously. Moreover, said oligosaccharides can be used alone or together with other anticancer agents, e.g. cytotoxics such as docetaxel or paclitaxel.
Claims51
A process for depolymerizing a polysaccharide with anti-thrombotic properties, for obtaining a product having anti-cancer properties, comprising a step in which the polysaccharide is depolymerized with heparinase 1 until its anti-thrombotic activity is essentially extinguished (<35 IU/mg), wherein the depolymerization is carried out at a temperature of between 10 and 20° C.
The product of formula (I)
- in which:
- R is chosen from H and SO3M, and
- M is chosen from H, Li, Na and K;
- with the exception of the product for which n=0, R═SO3M and M═Na.
The product of formula (Id):
The product of formula (Ie):
The product of formula (Ih):
The product of formula (Ij):
The product of formula (Im):
A method of inhibiting heparanase which comprises administering to a patient an effective amount of a product of formula (I):
- in which:
- R is chosen from H and SO3M, and
- M is chosen from H, Li, Na and K.
A method of inhibiting heparanase which comprises administering to a patient an effective amount of a product selected from the group consisting of:
Dependencies are inferred from the claim text.