Method for inducing hepatocyte proliferation and uses thereof
AssigneeCan-Fite Biopharma Ltd.
InventorsPnina Fishman, Shira Cohen
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Abstract
The present application provides methods and compositions for inducing hepatocyte proliferation and liver regeneration, the latter being mainly dependent on hepatocyte proliferation even if all the other cell types divide to reconstitute the organ specific-lobular-architecture. The methods and compositions provided herein make use of an A3AR agonist. A preferred A3AR agonist disclosed herein is Cl-IB-MECA.
Claims16
1-18. (canceled)
A method of stimulating hepatocyte proliferation, comprising providing to a hepatocyte an agonist of the A3 adenosine receptor (A3AR agonist) in an amount effective to stimulate hepatocyte proliferation.
An A3AR agonist for use in a method for stimulating hepatocyte proliferation.
An A3AR agonist for use in a method for treating a patient having liver damage due to hepatectomy.
Dependencies are inferred from the claim text.