Beta glycolipids for the treatment of calcification related degenerative disorders
OwnerYaron Ilan, Haim Lotan +2inventors
InventorsYaron Ilan, Haim Lotan, Mony Shuvy, Gadi Lalazar
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OwnerYaron Ilan, Haim Lotan +2inventors
InventorsYaron Ilan, Haim Lotan, Mony Shuvy, Gadi Lalazar
Estimating the term…
The present invention relates to a composition comprising a combination of at least one natural or synthetic β-glycolipid, a mixture of at least two β-glycolipids, a substance which increases the intracellular, extracellular or serum level of a naturally occurring β-glycolipid, or any combination or mixture thereof and at least one phosphate inhibitor or any compound that alters the phosphate binding or transporting into or out of any cell or any membrane or any combination thereof. The combined composition of the invention may be particularly used for treating calcification related degenerative disorders, specifically, vascular and valvular disorders. The invention further provides kits methods and uses thereof for treatment of calcification related disorders.
A composition comprising a combination of at least one natural or synthetic β-glycolipid, a mixture of at least two β-glycolipids, a substance which increases the intracellular, extracellular or serum level of a naturally occurring β-glycolipid, or any combination or mixture thereof and at least one phosphate inhibitor or any compound that alters the phosphate binding or transporting into or out of any cell or any membrane or any combination thereof, said composition optionally further comprising at least one pharmaceutically acceptable carrier, diluent, excipient and/or additive.
(canceled)
A kit for achieving a therapeutic effect in a subject in need thereof comprising:
A method for the treatment or prevention of a calcification related degenerative disorder in a subject in need thereof, which method comprises the step of administering to said subject a therapeutically effective amount of at least one of:
(canceled)
-22. (canceled)
A method for protection of cells of the endothelial lining from a vascular or valvular degenerative process comprising the step of contacting said cells with a protective effective amount of at least one of (a) any one of β-glycolipid, a mixture of at least two β-glycolipids and a substance which increases the intracellular, extracellular or serum level of a naturally occurring β-glycolipid;
A method for decreasing RANKL expression in a subject in need thereof, and thereby blocking TNF family pathway, wherein said reduction of RANKL expression reduces NFκB activation, said method comprising the step of administering to said subject an effective amount of at least one of:
Dependencies are inferred from the claim text.