Biogel
AssigneeHaemostatix Limited
InventorGreg Walker
Life of this patent
Estimating the term…
Abstract
A biogel, and kits, agents, and methods for formation of the biogel are described. The biogel can be used for a variety of applications, including haemostasis, wound sealing, tissue engineering or localised drug delivery.
Claims20
1-15. (canceled)
An agent for formation of a biogel, the agent being selected from:
- (i) an agent comprising a soluble carrier, wherein a plurality of fibrinogen binding moieties are immobilized to each carrier;
- and
- (ii) an agent comprising one or more insoluble carriers each having immobilized thereto a plurality of fibrinogen binding moieties, wherein said agent which comprises one or more insoluble carriers comprises a powder formed other than by lyophilization.
17-19. (canceled)
A biogel that is selected from the group consisting of:
- (a) a biogel which comprises fibrinogen molecules and a plurality of carriers, wherein each carrier has a plurality of fibrinogen binding moieties immobilized to the carrier, and each molecule of fibrinogen is bound to at least two fibrinogen binding moieties, so that the fibrinogen molecules are linked together via the carriers by non-covalent bonds between the fibrinogen binding moieties and the fibrinogen molecules;
- (b) a biogel which comprises fibrin monomers and a plurality of carriers, wherein each carrier has a plurality of fibrinogen binding moieties immobilized to the carrier, and the fibrin monomers are linked together via the carriers by non-covalent bonds between the fibrinogen binding moieties and the fibrin monomers;
- and
- (c) a biogel which comprises fibrin and a plurality of carriers, each carrier having a plurality of fibrinogen binding moieties immobilized to the carrier, wherein fibrin monomers of the fibrin are covalently linked together by peptide bonds and fibrin monomers of the fibrin are linked together via the carriers by non-covalent bonds between the fibrinogen binding moieties and the fibrin monomers.
22-23. (canceled)
27-28. (canceled)
A method of forming a powdered agent for use in the formation of a biogel, comprising spray drying a solution which comprises an agent comprising a soluble carrier having a plurality of fibrinogen binding moieties.
31-32. (canceled)
35-42. (canceled)
Dependencies are inferred from the claim text.