Antagonists of the receptor for advanced glycation end-products (rage)
AssigneeBoard of Regents, The University of Texas System
InventorsCraig D. Logsdon, Thiruvengadam Arumugam
Life of this patent
Estimating the term…
Abstract
Novel peptides are useful as antagonists of RAGE and may be used to treat cancer, inflammation, diabetes and arthritis through the administration of a therapeutically effective amount of the peptide to a subject in need thereof.
Claims23
An isolated peptide comprising an amino acid sequence of SEQ ID NO:
- 1.
An isolated peptide comprising an amino acid sequence of SEQ ID NO:
- 2.
An isolated peptide comprising an amino acid sequence of SEQ ID NO:
- 3.
An isolated peptide comprising an amino acid sequence of SEQ ID NO:
- 4.
An isolated peptide comprising an amino acid sequence of SEQ ID NO:
- 5.
A method of inhibiting RAGE comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 1 to a subject in need thereof.
A method of inhibiting RAGE comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 3 to a subject in need thereof.
A method of inhibiting RAGE comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 4 to a subject in need thereof.
A method of inhibiting RAGE comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 4 to a subject in need thereof.
A method of treating cancer comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 1 to a subject in need thereof.
A method of treating cancer comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 3 to a subject in need thereof.
A method of treating cancer comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 4 to a subject in need thereof.
A method of inhibiting RAGE comprising administering a therapeutically effective amount of a peptide having an amino acid sequence of SEQ ID NO:
- 5 to a subject in need thereof.
An isolated nucleic acid comprising a sequence that encodes a peptide consisting of the amino acid sequence of SEQ ID NO:
- 1.
An isolated nucleic acid comprising a sequence at least 90% identical to SEQ ID NO:
- 6, wherein the nucleic acid encodes a polypeptide that binds to RAGE.
A method of inhibiting RAGE comprising administering a therapeutically effective amount of a nucleic acid sequence comprising a nucleic acid sequence of SEQ ID NO:
- 6 to a subject in need thereof.
Dependencies are inferred from the claim text.