Animal Model For Infant Pathologies
AssigneeMead Johnson Nutrition Company
InventorsKristin Morris, Eduard Poels, Hugh Tucker
Life of this patent
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Abstract
A method of providing an animal model for at least one infant pathology, including delivering an animal prior to full physical development; performing a surgical procedure on the animal to provided capacity for respiratory assistance and nutrition; exposing the animal to varying concentrations of oxygen; and optionally repeating the exposure of the animal to varying concentrations of oxygen until the desired condition develops.
Claims21
A method of providing a piglet model for retinopathy, the method comprising:
- a) providing a preterm piglet with the piglet delivered prior to full physical development;
- b) monitoring at least one physiological condition of the piglet;
- c) performing a surgical procedure on the piglet to provided capacity for respiratory assistance and nutrition;
- d) exposing the piglet to varying concentrations of oxygen;
- and
- e) optionally repeating the exposure of the piglet to varying concentrations of oxygen until the desired retinopathy develops.
12 The method of claim 10 wherein the piglet is exposed to high concentrations of oxygen for a total time of about 30 minutes to about 90 minutes.
A method of simulating conditions of a human infant in a neonatal intensive care unit, the method comprising:
- a) providing a preterm non-human animal, the non-human animal delivered prior to full physical development;
- b) monitoring at least one physiological condition of the non-human animal;
- c) performing a surgical procedure on the non-human animal to provided capacity for respiratory assistance and nutrition;
- d) exposing the non-human animal to varying concentrations of oxygen to a provide neonatal intensive care unit non-human animal model;
- and
- e) observing the neonatal intensive care unit non-human animal model for pathologies associated with a human infant in a neonatal intensive care unit.
A method for testing the effects of a therapeutic agent for treating retinopathy, the method comprising:
- a) providing a preterm piglet, the piglet delivered prior to full physical development;
- b) monitoring at least one physiological condition of the piglet;
- c) performing a surgical procedure on the piglet to provided capacity for respiratory assistance and nutrition;
- d) exposing the piglet to varying concentrations of oxygen to induce retinopathy in the piglet;
- and
- e) administering at least one therapeutic agent to the piglet with retinopathy.
Dependencies are inferred from the claim text.