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US 2010/0249029 A1Published application
Peptides with high affinity for the prolactin receptor
AssigneeNovo Nordisk A/S
InventorsJens Breinholt, Kent Bondensgaard, Leif Christensen, Leif Nørskov-Lauritzen, Wang Lingyun, Gong Wei, Liu Yun, Sean Hu, Quinhong Ma
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Abstract
The invention relates to variants of prolactin, which variants have high affinity for the prolactin receptor.
Claims51
An isolated peptide, which peptide is a variant of a PRL-like cytokine, said variant comprising
- (i) one or more amino acid mutations in the region corresponding to amino acid residue 24 to 35 of SEQ ID No. 1 and/or
- (ia) one or more amino acid mutations in the region corresponding to amino acid residue 52 to 58 of SEQ ID No. 1 and/or
- (ib) one or more amino acid mutations in the region corresponding to amino acid residue 50 to 57 of SEQ ID No. 1 and/or
- (ii) one or more amino acid mutations in the region corresponding to amino acid residue 66 to 83 of SEQ ID No. 1 and/or
- (iii) one or more amino acid mutations in the region corresponding to amino acid residue 176 to 199 of SEQ ID No. 1 and/or
- (iv) an addition of from 1 to 5 amino acid residues to the C-terminal.
3 more elements
An isolated peptide, which peptide is a variant of a PRL-like cytokine, said variant comprising one or more amino acid mutations, which stabilizes the structure of the prolactin molecule.
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Dependencies are inferred from the claim text.