Detection of contrast medium-induced nephrotoxicity
OwnerGeorg Hess, Andrea Horsch +1inventors
InventorsGeorg Hess, Andrea Horsch, Dietmar Zdunek
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Abstract
The present invention relates to a method for diagnosing contrast medium-induced nephrotoxicty in a subject based on comparing the amount of urotensin II and/or adiponectin in a sample of the subject obtained after administration of the contrast medium to the amount of urotensin II and/or adiponectin in a sample of the subject prior to administration of the contrast medium. Further encompassed by the present invention are a kit and a device for carrying out the method of the present invention.
Claims10
A method for diagnosing a contrast medium-induced nephrotoxicity in a subject, the method comprising the steps of:
- obtaining a first urine sample from the subject prior to administering the contrast medium,
- determining an amount of adiponectin in the first sample,
- obtaining a second urine sample from the subject, wherein the second sample is obtainer 12 to 48 hours after administering the contrast medium,
- determining, in a second urine sample of the subject obtained after administering the contrast medium, the amount of adiponectin;
- and
- comparing the amount of adiponectin determined in the first sample to the amount of adiponectin determined in the second sample, wherein an increase in the amount of adiponectin in the second sample compared with the amount in the first sample indicates contrast medium-induced nephrotoxicity.
A device for diagnosing contrast medium-induced nephrotoxicity in a subject comprising
- a means for determining an amount of adiponectin in multiple urine samples from a subject, and
- a means for comparing an amount of adiponectin determined in a first urine sample from the subject with an amount of adiponectin determined in a second urine sample, whereby diagnosis of contrast medium-induced nephrotoxicity is allowed.
Dependencies are inferred from the claim text.