SENSE OLOGONUCLEOTIDE CAPABLE OF CONTROLLING THE EXPRESSION OF iNOS AND COMPOSITION COMPRISING THE SAME
AssigneeAmino Up Chemical Co., Ltd.
InventorsTadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
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Abstract
The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
Claims11
A sense oligonucleotide having a sequence complementary to iNOS mRNA antisense RNA (antisense transcript of iNOS mRNA) having a sequence complementary to iNOS (inducible nitric oxide synthase) mRNA.
A method of controlling a production amount of iNOS, wherein sense oligonucleotide having a sequence complementary to iNOS mRNA antisense RNA (antisense transcript of iNOS mRNA) is introduced in the cell.
Dependencies are inferred from the claim text.