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US 2010/0248363 A1Published application
Matrices and media for storage and stabilization of biomolecules
AssigneeGenVault Corporation
InventorsMichael Hogan, Michael Saghbini, David Wong, Chunnian Shi
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Abstract
The present invention provides compositions useful for biomolecule storage comprising a water soluble inorganic compound, a stabilizer, or a combination thereof. The present invention also provides methods of using the compositions of the invention to store biomolecules in the dry state and in solution, as well as sample carriers and kits comprising compositions of the invention.
Claims45
A dry-state matrix comprising:
- an inorganic compound;
- and
- a stabilizer, a plasticizer, or a combination thereof,
- wherein the stabilizer is selected from the group consisting of a singlet oxygen quencher, a hydroxyl radical scavenger, a hydroperoxide removing agent, a reducing agent, a metal chelator, a detergent, a chaotrope, or any combination thereof, and
- wherein said inorganic compound is water soluble and wherein the matrix is in solid state.
2 more elements
A dry-state matrix comprising:
- an inorganic compound;
- and
- a sample comprising biomolecules,
- wherein said inorganic compound is water soluble and wherein said matrix is in solid state.
1 more element
A dry-state matrix comprising:
- a stabilizer comprising a singlet oxygen quencher, a hydroxyl radical scavenger, a hydroperoxide removing agent, a reducing agent, a chelator, a detergent, a chaotrope, or any combination thereof, and
- an inorganic salt, a plasticizer, or any combination thereof,
- wherein said matrix is in solid state.
A dry-state matrix comprising:
- at least three components selected from the list consisting of an inorganic compound, a singlet oxygen quencher, a hydroxyl radical scavenger, a hydroperoxide removing agent, a reducing agent, a metal chelator, a detergent, and a plasticizer,
- wherein said inorganic compound is water soluble, and wherein said matrix is in solid state.
An aqueous medium comprising:
- an inorganic compound;
- a stabilizer, a plasticizer, or a combination thereof, and
- optionally, an RNase inhibitor,
- wherein said stabilizer is selected from the group consisting of a singlet oxygen quencher, a hydroxyl radical scavenger, a hydroperoxide removing agent, and any combination thereof, and
- wherein said inorganic compound is water soluble.
2 more elements
An aqueous medium comprising:
- one or more hydroxyl radical scavengers;
- an inorganic salt, a plasticizer, or any combination thereof, and
- optionally, an RNase inhibitor.
Dependencies are inferred from the claim text.