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US 2010/0248313 A1Published application
Novel optically active, heteroaromatic beta-hydroxy esters and processes for their preparation from beta-keto esters and processes for the preparation of these beta-keto esters
AssigneeBayer Schering Pharma Aktiengesellschaft
InventorsJohannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa, Orlin Petrov
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Abstract
The present invention relates to new optically active heteroaromatic β-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
Claims25
A compound of general formula I,
- wherein:
- A is a bicyclic heteroaromatic residue of formula
- wherein “heteroaromatic” stands for a 5- or 6-membered heteroaromatic ring having up to 2 heteroatoms selected from oxygen, nitrogen or sulphur, which is optionally substituted with one or two substituents selected from alkyl, optionally protected hydroxyalkyl, halo-alkyl, halogen or CN, and R is a straight-chain or branched, optionally saturated alkyl chain, which optionally contains 1-3 oxygen atoms;
- phenyl;
- cyclohexyl;
- or benzyl residue.
3 more elements
A compound as claimed in 14, wherein R is methyl or ethyl.
Dependencies are inferred from the claim text.