Method for Identifying a Compound that Modulates Telomerase Activity
AssigneeThe Wistar Institute
InventorEmmanuel Skordalakes
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Abstract
The present invention relates to a method for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain of telomerase and testing the compound for its ability to modulate the activity of telomerase.
Claims37
A method for identifying a compound which modulates the activity of telomerase comprising
- (a) designing or screening for a compound which binds to at least one amino acid residue of the TRBD domain of telomerase;
- and
- (b) testing the compound designed or screened for in (a) for its ability to modulate the activity of telomerase, thereby identifying a compound that modulates the activity of telomerase.
A method for identifying a compound which modulates the activity of telomerase comprising
- (a) designing or screening for a compound which binds to at least one amino acid residue of the nucleotide binding pocket;
- and
- (b) testing the compound designed or screened for in (a) for its ability to modulate the activity of telomerase,
- thereby identifying a compound that modulates the activity of telomerase.
A method for identifying a compound which modulates the activity of telomerase comprising
- (a) designing or screening for a compound which binds to at least one amino acid residue in direct contact with DNA;
- and
- (b) testing the compound designed or screened for in (a) for its ability to modulate the activity of telomerase, thereby identifying a compound that modulates the activity of telomerase.
Dependencies are inferred from the claim text.