Purinergic (p2x) receptors in extra-cellular body fluid
AssigneeBiosceptre International Limited
InventorsAngus Gidley-Baird, Julian Alexander Barden
Life of this patent
Estimating the term…
Abstract
The invention relates to purinergic (P2X) receptors, to detection of protein in extra-cellular body fluids and to antibodies for the diagnosis of a disease or condition, especially cancer.
Claims21
-22. (canceled)
A purinergic (P2X) receptor, monomer or fragment thereof obtainable from an extracellular body fluid.
A substantially pure purinergic (P2X) receptor obtainable by a method including the steps of
- providing a sample of extra-cellular body fluid or tissue biopsy obtained from an individual;
- contacting the sample with an anti purinergic (P2X) receptor antibody or fragment thereof in conditions for forming an immune complex between a purinergic (P2X) receptor, monomer or fragment thereof in the extra-cellular body fluid in the sample and the antibody or fragment thereof;
- and
- eluting the purinergic (P2X) receptor, monomer or fragment thereof in the immune complex,
- thereby producing substantially pure purinergic (P2X) receptor.
A method for determining whether an individual has cancer, or is predisposed to cancer including the steps of:
- providing a sample of extra-cellular body fluid or tissue biopsy obtained from an individual in whom the presence or absence of cancer or predisposition thereto is to be determined;
- contacting the sample with an anti purinergic (P2X) receptor antibody or fragment thereof in conditions for forming an immune complex between a purinergic (P2X) receptor, monomer or fragment thereof in the extra-cellular body fluid in the sample and the antibody or fragment thereof;
- and
- detecting whether the immune complex has been formed, thereby determining whether the individual has a cancer or predisposition thereto.
A method for determining whether an individual has cancer or is predisposed to cancer including the steps of:
- administering an anti purinergic (P2X) receptor antibody or fragment thereof to an individual in whom the presence or absence of cancer or predisposition thereto is to be determined in conditions for foaming an immune complex between the antibody or fragment thereof and a purinergic (P2X) receptor, monomer or fragment thereof in the extra-cellular body fluid of the individual;
- and
- detecting whether the immune complex has been formed to determine whether the individual has a cancer or predisposition thereto.
Dependencies are inferred from the claim text.