Compositions and methods for diagnosis and treatment of cancer
AssigneeThe Salk Institute for Biological Studies
InventorsTony Hunter, Jeremy T. Copp
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and compositions useful in the diagnosis and treatment of cancer. The methods and compositions typically involve detecting a level of phosphorylation of mTOR at serine 2481 in a subject and comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard control.
Claims12
A method of predicting whether a subject that has a cancer would be responsive to an mTOR inhibition cancer treatment, said method comprising:
- (i) detecting a level of phosphorylation of mTOR at serine 2481 in said subject;
- (ii) comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard control, wherein a high level of phosphorylation of mTOR at serine 2481 in said subject relative to said standard control indicates said subject would be responsive to an mTOR inhibition cancer treatment.
A method of monitoring progression of a cancer in a subject that has said cancer, said method comprising:
- (i) detecting a level of phosphorylation of mTOR at serine 2481 in said subject;
- (ii) comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard control, wherein a high level of phosphorylation of mTOR at serine 2481 in said subject relative to said standard control indicates a higher progression of cancer in said subject.
A method of determining whether a subject is at risk of developing a cancer, said method comprising:
- (i) detecting a level of phosphorylation of mTOR at serine 2481 in said subject;
- (ii) comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard control, wherein a high level of phosphorylation of mTOR at serine 2481 in said subject relative to said standard control indicates said subject is at risk of developing said cancer.
A method of determining whether a subject has a cancer, said method comprising:
- (i) detecting a level of phosphorylation of mTOR at serine 2481 in said subject;
- (ii) comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard control, wherein a high level of phosphorylation of mTOR at serine 2481 in said subject relative to said standard control indicates said subject has said cancer.
A method of determining whether a test compound is a cancer therapeutic, said method comprising:
- (i) contacting said test compound with a cell;
- (ii) detecting a level of phosphorylation of mTOR at serine 2481 in said cell;
- (iii) comparing said level of phosphorylation of mTOR at serine 2481 to a standard control, wherein a high level of phosphorylation of mTOR at serine 2481 in said cell relative to said standard control indicates said test compound is a cancer therapeutic.
Dependencies are inferred from the claim text.