Novel peptides
AssigneesKyowa Hakko Kogyo Co., Ltd., Japan AS Represented By President of National Cardiovascular Center, Osaka University
InventorsMotoo Yamasaki, Noriyuki Takahashi, Naoto Minamino, Kazuki Sasaki, Toshifumi Takao, Yoshinori Satomi
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Abstract
The present invention provides novel peptides with circulation-modulating activity. These peptides are useful as circulation-modulating agents and vasopressors because of their circulation-modulating activity, and can be used for treating diseases of the circulatory system such as myocardial infarction, ischemic heart disease, cerebral infarction, or the like.
Claims12
A peptide of any one of (a) to (e) below or a pharmaceutically acceptable salt thereof:
- (a) a peptide comprising the amino acid sequence of any one of SEQ ID NOS:
- 1 to 4, 28 and 29 (but excluding peptides comprising the amino acid sequence of SEQ ID NOS:
- 9, 30, 31, 32 or 33);
- (b) a peptide comprising an amino acid sequence with substitution, deletion, or addition of one to five amino acids in the amino acid sequence of any one of SEQ ID NOS:
- 1 to 4, 28 and 29, wherein the peptide has an activity of increasing the intracellular calcium ion concentration of cardiac or vascular cells;
- (c) a peptide comprising an amino acid sequence having 90% or higher homology to the amino acid sequence of any one of SEQ ID NOS:
- 1 to 4, 28 and 29, wherein the peptide has an activity of increasing the intracellular calcium ion concentration of cardiac or vascular cells;
- (d) a peptide represented by the following formula (I) (but excluding peptides comprising the sequences of SEQ ID NOS:
- 14 to 16),
- Z1-A-Z2 (I)
- (wherein, Z1 represents a hydrogen atom or a peptide residue of any sequence comprising one to eleven amino acids, A represents a peptide residue comprising the amino acid sequence of SEQ ID NO:
- 17, and Z2 represents an amino group or a peptide residue of any sequence comprising one to 38 amino acids);
- and
- (e) a peptide represented by the following formula (II)
- R1—B—R2 (II)
- (wherein, R1 represents a hydrogen atom, substituted or unsubstituted alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroarylcarbonyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aryloxycarbonyl, or substituted or unsubstituted heteroaryloxycarbonyl;
- R2 represents hydroxy, substituted or unsubstituted alkoxy, or substituted or unsubstituted amino;
- and B represents a peptide residue of the peptide of any one of the above-mentioned (a) to (d)).
An antibody that binds to an epitope present in the amino acid sequence of SEQ ID NO:
- 4 or a sequence wherein the C terminus of the amino acid sequence of SEQ ID NO:
- 4 is amidated.
Dependencies are inferred from the claim text.