Method and kit for assessing risk of gout and hyperuricemia
AssigneeKaohsiung Medical University
InventorsYing-Chin Ko, Shun-Jen Chang, Shu-Jung Wang, Shang-Lun Chiang
Life of this patent
Estimating the term…
Abstract
A method for assessing a risk of suffering from a gout of a subject is provided. The method includes steps of obtaining a nucleotide sample from the subject; determining a genetic polymorphism of one of a Urate transporter 1 (URAT1) gene and an alpha-kinase 1 (ALPK1) gene in the nucleotide sample, wherein the genetic polymorphism is associated with an occurrence of the gout; and comparing the genetic polymorphism with a predetermined genetic polymorphism so as to assess the risk of suffering from the gout of the subject.
Claims20
A method for assessing a risk of suffering from a gout of a subject, comprising steps of:
- obtaining a nucleotide sample from the subject;
- determining a genetic polymorphism of one of a Urate transporter 1 (URAT1) gene and an alpha-kinase 1 (ALPK1) gene in the nucleotide sample, wherein the genetic polymorphism is associated with an occurrence of the gout;
- and
- comparing the genetic polymorphism with a predetermined genetic polymorphism so as to assess the risk of suffering from the gout of the subject.
A method for determining a hyperuricemia susceptibility of a subject, the method comprising steps of:
- obtaining a nucleotide sample from the subject;
- identifying a genetic polymorphism in one of a Urate transporter 1 (URAT1) gene and an alpha-kinase 1 (ALPK1) gene in the nucleotide sample, wherein the genetic polymorphism is associated with an occurrence of the hyperuricemia;
- and
- comparing the genetic polymorphism with a predetermined genetic polymorphism so as to determine the hyperuricemia susceptibility of the subject.
A kit detecting one of a Urate transporter 1-rs3825016 C marker and a alpha-kinase 1-rs231247 G marker, so as to determine one of a gout susceptibility and a hyperuricemia susceptibility of a subject.
Dependencies are inferred from the claim text.