Treating surfaces to enhance bio-compatibility
OwnerKadem Gayed Al-Lamee, Martyn Peter Lott +2inventors
InventorsKadem Gayed Al-Lamee, Martyn Peter Lott, Diane Cook, Stuart Bayes
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Abstract
Described is a method of treating an article having at its surface oxide or hydroxide moieties, as well as the resulting treated article. The method includes priming the surface of the article by contact with an alkoxysilane in an aprotic organic solvent in the presence of an acid catalyst so that the alkoxysilane reacts with the oxide or hydroxide moieties of the surface. This yields a primed surface. A polymer is then reacted with one or more amino, hydroxyl, carboxylic acid and/or acid anhydride groups on the surface to covalently couple the polymer to the primed surface via the alkoxysilane. The reaction with the polymer is not a free-radical reaction.
Claims41
A method of treating an article having at its surface oxide or hydroxide, said method comprising the steps of:
- priming said surface by contact with an alkoxysilane in an aprotic organic solvent in the presence of an acid catalyst so that the alkoxysilane reacts with the oxide or hydroxide of said surface to form covalent bonds, the alkoxysilane comprising one or more amino, hydroxyl, carboxylic acid or acid anhydride groups, thereby yielding a primed surface;
- and
- reacting a polymer with one or more of said amino. hydroxyl, carboxylic acid and/or acid anhydride groups to covalently couple said polymer to said primed surface via said alkoxysilane, wherein the reaction with the polymer is not a free-radical reaction.
A method of treating an article having at its surface amino groups, said method comprising the steps of:
- (a) reacting the surface with a molecule having an isocyanate group and a pendent alkoxysilane group, so that the isocyanate group reacts with said amino group to form a urea linkage, and (b) covalently coupling a polymer having at least one pendent hydroxyl group to the surface by reaction between the hydroxyl group and said pendent alkoxysilane group.
Dependencies are inferred from the claim text.