Method for producing granulated preparation
OwnerHiroshi Sakamoto, Toshiya Taniguchiinventors
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Abstract
It has been desired to provide a method for producing a granulated preparation capable of maintaining a stability of a chemically unstable substance in a neutral or acidic region for a long period of time with a simple and safe method in a preparation procedure, and a tablet produced by using the method. The invention provides a granulation method in which an unstable substance is successively subjected to aqueous stabilization treatment and granulation procedure. Further, it became possible to provide a tablet which is absorbed in the intestine without losing the potency in a gastric region by forming an intermediate layer on a surface of the thus obtained granule and subsequently subjecting the granule to enteric coating.
Claims12
A method for producing a granulated preparation, which comprises supplying particles of a stabilizing agent or an excipient to a fluidized bed granulator, and spraying a liquid in which an unstable substance has been dissolved or suspended in an aqueous solution or aqueous suspension of the stabilizing agent while keeping a fluidized state.
Dependencies are inferred from the claim text.