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OwnerDaniel H. Maes, Jules Zecchinoinventors
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The present invention provides compositions containing a mixture of cholesterol sulfate and an exfoliant. The exfoliant can be N-acetyl-D-glucosamine, N-acetylgalactosamine, or a combination thereof. The combination of cholesterol sulfate with the exfoliant surprisingly enhances the skin barrier even though the activity of each of the components is opposite the other. In addition, because of the ability to enhance or repair the skin barrier function, methods of maintaining or improving a healthy skin barrier are included in the present invention by apply to the skin an effective amount of the mixture of cholesterol sulfate with the exfoliant. The mixture can also be useful in treating or preventing damage to the skin, where the damage is caused by a comprised skin barrier function. As a result of improved skin barrier function, the appearance of lines and wrinkles is generally reduced; rough and dry skin conditions are also improved.
A composition for topical application to the skin comprising a mixture of cholesterol sulfate or salts thereof present in an amount between 0.05 to about 5.00 percent by weight of the composition with an exfoliant present in an amount between 0.1 to about 10.0 percent by weight of the composition in a cosmetically or pharmaceutically acceptable vehicle.
A cosmetic or pharmaceutical formulation for topical application of a composition to the skin, the formulation containing a mixture comprising cholesterol sulfate or salts thereof in an amount from about 0.05 to about 5.00 percent, and from about 0.1 to about 10.0 percent by weight of an amino sugar selected from the group consisting of N-acetyl-D-glucosamine, N-acetylgalactosamine, and a combination thereof by weight of the composition in a cosmetically or pharmaceutically acceptable vehicle.
A method for improving or maintaining a healthy skin barrier which comprises adding an effective amount of a mixture to a cosmetically or pharmaceutically acceptable vehicle wherein said mixture comprises cholesterol sulfate or salts thereof in an amount from about 0.05 to about 5.00 percent by weight of the composition, and from about 0.1 to 10.0 percent by weight of the composition an amino sugar selected from the group consisting of N-acetyl-D-glucosamine, N-acetylgalactosamine, and a combination thereof, and applying said vehicle containing said mixture to the skin.
A method of treating or reducing damage to the skin, wherein the damage is associated with a reduction or loss of skin barrier function, which comprises adding an effective amount of a mixture to a cosmetically or pharmaceutically acceptable vehicle wherein said mixture comprises cholesterol sulfate or salts thereof in an amount from about 0.05 to about 5.00 percent by weight of the composition, and about 0.1 to about 10.0 percent of an amino sugar selected from the group consisting of N-acetyl-D-glucosamine, N-acetylgalactosamine, and a combination thereof by weight of the composition, and applying said vehicle containing said mixture to the skin.
Dependencies are inferred from the claim text.