Methods of identifying potential components for targeted drug delivery compositions
AssigneeWarsaw Orthopedic, Inc.
InventorsJosee Roy, Victor Kelley, Roger E. Harrington
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Abstract
Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.
Claims18
A method of preparing compositions for preferential distribution of active agents, the method comprises:
- preparing a solution comprising a delivery ligand and one or more active agents;
- subjecting the solution to one or more conditions to induce separation of phases in the solution;
- and
- isolating a phase comprising delivery ligand-active agent complexes.
A method of identifying potential components for compositions for preferential distribution of active agents, the method comprises:
- preparing a solution comprising a delivery ligand and one or more active agents;
- subjecting the solution to one or more conditions to induce separation of phases in the solution;
- and
- determining whether one or more phases comprise delivery ligand-active agent complexes.
Dependencies are inferred from the claim text.