Compositions and Methods to Modulate Angiogenesis
OwnerCsaba Szaboinventor
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Abstract
The present invention provides methods of stimulating angiogenesis and the growth or migration of cells associated with angiogenesis, by contacting animals, tissues, or cells with sulfide, alone or in combination with nitric oxide. These methods may be used for a variety of purposes, including promoting wound healing, increasing blood flow, and for the treatment and prevention of diseases and disorders associated with decreased blood flow, including ischemic or hypoxic injury.
Claims31
A method of stimulating angiogenesis in an animal, tissue or organ, comprising administering to the animal, tissue or organ an effective amount of sulfide.
A method of stimulating angiogenesis in an animal or an animal tissue or organ, comprising administering to the animal, organ or tissue an effective amount of sulfide in combination with an effective amount of nitric oxide.
A method for promoting wound healing in an animal, comprising administering to the animal an effective amount of sulfide, alone or in combination with an effective amount of nitric oxide.
A method for promoting re-epithelialization of a denuded area of skin of an animal after a burn, trauma, wound, injury, chemotherapy, skin reaction following drug treatment or disease process, comprising administering to the animal an effective amount of sulfide, alone or in combination with an effective amount of nitric oxide.
A method for increasing blood flow to ischemic tissue, comprising administering to the tissue an amount of sulfide effective to stimulate angiogenesis and increase blood flow to said ischemic tissue.
A method for treating or preventing an injury or disease associated with decreased or insufficient blood flow in an animal, comprising administering to said animal an effective amount of sulfide, alone or in combination with an effective amount of nitric oxide.
A method of increasing, promoting, or stimulating growth, proliferation, or migration of a cell associated with angiogenesis, comprising contacting said cell with an effective amount of sulfide.
Dependencies are inferred from the claim text.