Compositions and Methods for Preferential Distribution of Active Agents to Injury Sites
AssigneeWarsaw Orthopedic, Inc.
InventorsJosee Roy, Toya Kimble
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Abstract
Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
Claims22
A method of preferential distribution of one or more active agents to a site of injury comprising:
- identifying a patient having an organ affected by a biological condition known to cause vessels supplying the organ to leak;
- and
- administering to the patient a composition comprising a delivery ligand and one or more active agents at a dose of about 0.5 to about 10 ml of composition per kg of patient's weight.
A method of treating organs affected by one or more biological conditions known to cause vessels supplying the organ to leak by preferentially distributing an active agent known to treat the one or more biological conditions, the method comprising:
- identifying a patient having such an organ;
- and
- administering to the patient a composition comprising a delivery ligand and one or more active agents at a dose of about 0.5 to about 10 ml of composition per kg of patient's weight.
A method of preferentially distributing magnesium to a site of neuronal injury, the method comprises:
- administering a composition comprising PEG and between about 0.1% and about 20% weight per volume of a compound comprising magnesium, wherein the compound comprising magnesium is distributed by PEG to the area surrounding the site of injury.
Dependencies are inferred from the claim text.