Polymer-agent conjugates, particles, compositions, and related methods of use
OwnerScott Eliasof, Thomas C. Crawford +3inventors
InventorsScott Eliasof, Thomas C. Crawford, Geeti Gangal, Lawrence Alan Reiter, Pei-Sze Ng
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Abstract
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
Claims43
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A particle comprising:
- a) a plurality of hydrophobic polymer-agent conjugates, wherein
- i) each hydrophobic polymer-agent conjugate of said plurality comprises a hydrophobic polymer attached to an agent,
- ii) said hydrophobic polymer attached to said agent can be a homopolymer or a polymer made up of more than one kind of monomeric subunit,
- iii) said hydrophobic polymer attached to said agent has a weight average molecular weight of about 4-15 kD,
- iv) said agent is about 1-30 weight % of said particle and
- v) said plurality of hydrophobic polymer-agent conjugates is about 25-80 weight % of said particle;
- b) a plurality of hydrophilic-hydrophobic polymers, wherein
- i) each of said hydrophilic-hydrophobic polymers of said plurality comprises a hydrophilic portion attached to a hydrophobic portion,
- ii) said hydrophilic portion has a weight average molecular weight of about 1-6 kD, and
- iii) said plurality of hydrophilic-hydrophobic polymers is about 5-30 weight % of said particle;
- and
- c) a surfactant, wherein said surfactant is about 15-35 weight % of said particle;
- and
- wherein:
- the diameter of said particle is less than about 200 nm.
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The particle of 26, comprising:
- a) a plurality of PLGA-agent conjugates, wherein
- i) each PLGA-agent conjugate of said plurality comprises a PLGA polymer attached to an agent,
- ii) the ratio of lactic acid to glycolic acid in said PLGA polymer attached to said agent is from about 25:75 to about 75:25,
- iii) said PLGA polymer attached to said agent has a weight average molecular weight of about 4-15 kD,
- iv) said agent is about 1-30 weight % of said particle and
- v) said plurality of PLGA-agent conjugates is about 25-80 weight % of said particle;
- b) a plurality of PEG-PLGA polymers, wherein
- i) each of said PEG-PLGA polymers of said plurality comprises a PEG portion attached to a PLGA portion,
- ii) said PEG portion has a weight average molecular weight of about 1-6 kD, wherein
- if the weight average molecular weight of said PEG portion is about 1-3 kD, the ratio of the weight average molecular weight of said PEG portion to the weight average molecular weight of said PLGA portion is between 1:3-1:7, and if the weight average molecular weight of said PEG portion is about 4-6 kD, the ratio of the weight average molecular weight of said PEG portion to the weight average molecular weight of said PLGA portion is between 1:1-1:4;
- and
- iii) said plurality of PEG-PLGA polymers is about 5-30 weight % of said particle;
- and
- c) PVA, wherein
- said PVA has a weight average molecular weight of about 5-45 kD and is about 15-35 weight % of said particle;
- and
- wherein:
- the diameter of said particle is less than about 200 nm.
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Dependencies are inferred from the claim text.