Biologic Modulations with Nanoparticles

A composition of a plurality of particles comprising a core provided by a bioactive component, surfacant molecules having an HLB value of less than about 6.0 units, said surfacant molecules being associated with the bioactive component, and a shell surrounding the association of the bioactive component and surfacant molecules, said shell comprising at least one biocompatible polymer, wherein at least one of said biocompatible polymers provides specific cellular or tissue uptake, wherein the particles have an average diameter of less than about 50 nanometers as measured by atomic force microscopy following drying of the collection of particles, and wherein at least one biocompatible polymer has a binding affinity for a cell recognition target from the group consisting of cell adhesion molecules, immunoglobulin superfamily, growth factor receptors, collagen receptors, laminin receptors, fibronectin receptors, chondroitin sulfate receptors, dermatan sulfate receptors, heparin sulfate receptors keratin sulfate receptors, elastin receptors, and vitronectin receptors.

A composition of a plurality of particles comprising a core provided by a bioactive component, surfactant molecules having an HLB value of less than about 6.0 units, said surfacant molecules being associated with the bioactive component, and a shell surrounding the association of the bioactive component and surfacant molecules, said shell comprising least one biocompatible polymer, wherein at least one of said biocompatible polymers provides specific cellular or tissue uptake, wherein the particles have and average diameter of less than about 50 nanometers as measured by atomic force microscopy of a plurality of the particles following drying of the particles, wherein the bioactive component is a member if the group consisting of anthracyclines, doxorubicin, vincristine, cyclophosphamide, topotecan, paclitaxel, modulators of apoptosis, and growth factors.

A method of delivering an anti-cancer agent to cancer cells, the method comprising contacting the cancer cells with a collection of particles comprising a core provided by a bioactive component, surfacant molecules having a HLB value of less than about 6.0 units, said surfacant molecules being associated with the bioactive component, and a shell surrounding the association of the bioactive component and surfacant molecules, said shell comprising at least one biocompatible polymer, wherein at least one of said biocompatible polymers provides specific cellular or tissue uptake, wherein the particles have an average diameter of less than about 50 nanometers measured by atomic force microscopy of a plurality of the particles following drying of the particles.